T-cell antigen receptor triggering and lipid rafts: a matter of space and time scales. Talking Point on the involvement of lipid rafts in T-cell activation

T-cell antigen receptor triggering mechanisms and lipid rafts are of broad interest, but are also controversial topics. Here, we review some recent progress in these two research fields, which has been accomplished mostl...

Ion channels: functional expression and therapeutic potential in cancer. Colloquium on Ion Channels and Cancer

It is becoming increasingly clear that TRP channels are involved in cancer progression (Bödding, 2007; Prevarskaya et al, 2007). In relation to prostate cancer, N. Prevarskaya (Villeneuve d'Ascq, France) describe...

A new regulatory loop in cancer-cell invasion

NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33ING1b

The tumour suppressor p33ING1b (ING1b for inhibitor of growth family, member 1b) is important in cellular stress responses, including cell-cycle arrest, apoptosis, chromatin remodelling and DNA repair; however, its degra...

Variations on complexity