Assessment and Comparison of Liver Functions in Leprosy
Journal Title: International Journal of Current Research and Review - Year 2017, Vol 9, Issue 5
Abstract
Leprosy is chronic infectious disease of man, caused by Mycobacterium leprae, affecting peripheral nerves, skin and sometimes other tissues. Hepatic involvement is seen in all stages of the leprosy, more so in lepra reactions. Aim: The present study was undertaken to evaluate hepatic status by studying the various liver function tests in leprosy patients as well as in patients of lepra reaction. Methodology: Sixty untreated leprosy patients (30 Multibacillary, 30 Paucibacillary) with duration of illness varying from one month to three years were considered. Hepatic functional status was evaluated by estimation and comparison of variations in the levels of liver enzymes, proteins (Albumin, Globulin) and Australia antigen in paucibacillary, multibacillary leprosy and type I&2 lepra reactions. Results: Deceased levels of serum albumin were noted in all forms of leprosy except in type II reaction while serum globulins were decreased only in paucibacillary leprosy. Raised levels of SGOT were found in all forms of leprosy including lepra reactions. However SGPT was significantly raised in type II lepra reaction. Serum bilirubin was raised in type II lepra reaction while raised levels of serum alkaline phosphatase were observed in type I lepra reaction. Serum cholesterol levels were decreased in all forms of leprosy except in type I reactions. Conclusion: We found that liver is significantly affected in leprosy and in lepra reactions. Assessment of liver functions is useful to measure the severity of affection of the liver in leprosy and for monitoring the patients on antileprosy treatment..
Authors and Affiliations
Dr. Archana G. Dhavalsahankh
Keywords
Related Articles
- EP ID EP602486
- DOI -
- Views 127
- Downloads 0
A Comparative Study on the Teaching Effectiveness of Chalk & Talk Versus Microsoft Powerpoint Presentation-An Institution Based Pilot Study of Physiotherapy Students
Background: In traditional classrooms, a teacher’s basic tools for displaying lectures are through chalkboards, pegboards, bulletin boards and walk and talk. To project instructional materials, transparencies with an ove...
Prevalence of Inducible Clindamycin Resistance of Staphylococcus aureus in Hospitalized Patients in Tertiary Care Hospital
Background: Methicillin resistant Staphylococcus aureus (MRSA) has emerged as one of the most common pathogen isolated from patients with very few drugs available for their treatment. Clindamycin is a good alternative op...
Fulvestrant Efficacy in Artificial Menopausal Hormone Receptor Positive and Human Epidermal Growth Factor Receptor 2 Negative Metastatic Breast Cancer Patients under 50 Years Old
Introduction: This study investigated the efficacy of fulvestrant in premenopausal patients with metastatic breast cancer who developed artificial menopause using a luteinizing hormone releasing hormone analogue. Methods...
Cognitive Functions in Patients of Type 2 Diabetes Mellitus with Peripheral Neuropathy, An Observational Cross Sectional Study Done in India
Background: Peripheral neuropathy and cognitive decline both are very common in diabetics but relationship between them is yet unclear. Hence, this study aimed at assessing the cognitive functions in patients of type 2 d...
Indian Diabetic Risk Score- A Tool For Predicting Risk Of Undiagnosed Type 2 Diabetes Mellitus
Objectives: The objective of the study was to assess the performance of the Indian Diabetic Risk Score (IDRS) questionnaire for detecting and predicting risk of Type 2 diabetes mellitus (T2DM) in patients attending a pri...