ASSESSMENT OF ANALGESIC, ANTIDIARRHOEAL AND CYTOTOXIC ACTIVITY OF ETHANOLIC EXTRACT OF THE WHOLE PLANT OF BACOPA MONNIERI LINN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
The ethanol extract of the whole plant of Bacopa monnieri Linn. (Scrophulariaceae) was investigated for its possible analgesic, antidiarrhoeal and cytotoxic activities in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 mg/kg & 500 mg/kg body weight (p<0.001) comparable to the standard drug Diclofenac sodium at the dose of 25 mg/kg of body weight. The extract showed antidiarrhoeal activity on castor oil induced diarrhoea in mice; it increased mean latent period and decreased the frequency of defecation significantly at the oral dose of 500 mg/kg body weight comparable to the standard drug Loperamide at the dose of 50 mg/kg of body weight. The crude extract produced the most prominent cytotoxic activity against brine shrimp Artemia salina (LC50 = 26.30 µg/ml).
Authors and Affiliations
Md. Siraj , Newton Chakma, Mahmudur Rahman, Salahuddin Malik , Samir Sadhu
Keywords
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