Assessment of Antibacterial Activity of Neem and Coriander Leaves Extract against Staphylococcus epidermidis and Propionibacterium acnes: Development and Evaluation of Herbal Anti-acne Gel
Journal Title: International Journal of Ayurveda and Pharmaceutical Chemistry - Year 2017, Vol 0, Issue 0
Abstract
Due to the increase in number of resistant bacterial strains, there is an urgent need for the development of alternative therapies for bacteria induced diseases. Herbal formulations presented good alternative due to their enhanced effect and less side effects. This study was aimed to develop a herbal formulation (gel) with a new combination containing extract of Neem (Azadirachta indica) and Coriander leaves (Coriandrum sativum) in the ratio of 2: 1.75.Neem leaves extract contain active compounds such as Azadirachtin, Nimbidin and Nimbinin, Gallic acid, Epicatechin, Margolone and Catechin which are responsible for antibacterial and antiinflammatory activity that can help in the treatment of acne vulgaris. Coriander leaves contain many important chemical constituents which are having pronounced antibacterial effects such as Plantaricin, an antimicrobial peptide containing 26 amino acids. Herbal gel formulations were developed by using the extract of Neem and Coriander leaves. Phytochemical analysis of extracts was performed to determine major chemical constituents in each of extract. Antibacterial activity was determined by disc diffusion method against strains of Staphylococcus epidermidis and Propionibacterium acnes. Propionibacterium acnes contributes to development of acne and Staphylococcus epidermidis considered to trigger inflammation along with Propionibacterium acnes and it is well documented. Activity of extracts was compared against standard antibiotic Clindamycin. Combination of Extracts of Neem and Coriander (2:1.75) showed maximum zone of inhibitions due to synergism but less as compared to Clindamycin. Two gel formulations G1 and G2 were developed and evaluated for physical parameters such as color, consistency, greasiness, odor, pH, viscosity and extrudability. These gels differs by the relative ratio of extracts of Neem and Coriander leaves, 1.75:2 for G1 and 2:1.75 for G2. G2 proved best formulation in term of antibacterial activity.
Authors and Affiliations
Tayyaba Sadiq, Muhammad Azeem
Keywords
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