ASSESSMENT OF COAGULATION PROFILE AND ITS CORRELATION WITH SEVERITY OF PREECLAMPSIA IN WOMEN OF ODISHA- A COMPARATIVE CROSS-SECTIONAL STUDY
Journal Title: International Journal of Basic and Applied Physiology - Year 2014, Vol 3, Issue 1
Abstract
Background: Preeclampsia is an idiopathic multisystem disorder. It is associated with alteration of haematological profile of which thrombocytopenia is the most common which may be accompanied by a clinically evident consumptive coagulopathy or may be the sole abnormality seen. Objective: The aim of the study is to compare the coagulation parameters in the patients with preeclampsia and normal pregnant women. Material and methods The study comprised of 100 pregnant women with preeclampsia in age group 18-35years. 100 healthy age matched pregnant women served as controls. Coagulation parameters done were total platelet count (TPC), prothrombin time (PT) activated partial thromboplastin time (aPTT), bleeding time (BT), coagulation time (CT) .The parameters were compared by using Student’s t-test. Result: In preeclamptic women, mean age group is 25.52 ± 4.38 years. A significant decline in platelet count (p<0.001), increase in PT (p<0.05), aPTT (p<0.001), BT (<0.001) and CT(p<0.05) was seen in preeclampsia as compared to normal pregnancy. With severe fall in platelet count in preeclamptic subjects prolongation of aPTT is more pronounced than PT. Conclusion: it is concluded from the study that total platelet count estimation can be taken as an early and rapid procedure for screening preeclampsia cases at admission followed by serial platelet counts while monitoring coagulation indices.
Authors and Affiliations
Girija Priyadarshini, Rama Raman Mohanty
Keywords
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