Assessment of Correlation of Haematological Profile and Early Onset of Infections in Neonates
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 2
Abstract
Background: Because of lack of specific clinical and laboratory findings, early diagnosis of neonatal septicemia is often difficult. Antibiotics are administered on suspicion of neonatal sepsis as early as possible whereas it takes some time to get reports from blood culture. To devise a way to early diagnosis and reduce the irrational use of antibiotics, several rapid haematological tests have been evaluated. This objective behind the study was to correlate the role of haematological parameters to early onset septicaemia in neonates and to establish it as a reliable indicator. Materials and Methods: A prospective study of haematological parameters of 300 neonates with clinically suspected sepsis was performed. These parameters were evaluated statistically based on the standard reference values. Results: Band cells, Increase/ decreased WBCs, neutropenia, I/M ratio, I/T ratio, Thrombocytopenia, Toxic granules were found to have good specificity and sensitivity. Most of the patients had two or more positive tests. Hematological scoring system had the sensitivity: 95.8%, specificity:73.8%, Positive predictive value:41%, Negative predictive value: 98.9%. Conclusion: It is concluded that the haematological parameters can provide an early clue for diagnosis of early onset septicaemia in neonates. Hematological scoring system if established can act as a rapid adjunct to diagnose and help in early intervention thereby decreasing neonatal morbidity and mortality.
Authors and Affiliations
Deepika Sharma, Ashish Batham
Keywords
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- EP ID EP538960
- DOI 10.21276/ijmrp.2018.4.2.032
- Views 90
- Downloads 0
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