Assessment of Diagnostic Value of Three Interleukin (1, 6 And 8) In Cerebrospinal Fluid of Children and Adolescent with Meningitis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Background: Meningitis is a serious infectious disease of the central nervous system (CNS) with severe complication and numerous mortality. Distinction between aseptic and bacterial meningitis by cerebrospinal fluid (CSF) culture can be difficult and long-term, and other diagnostic methods are under studying for prevention of bacterial meningitis complications. This study aimed to assess the diagnostic value of three CSF biomarkers including interleukin (1, 6 and 8) in the children and adolescent with meningitis. Methods: 51 children and adolescent (1month-18 years) with definite meningitis were included in a crosssectional analytic study. In addition to analysis and culture of CSF, interleukin-1,6,8 levels were determined by ELIZA method in CSF samples obtained from all cases . Results: Frequency of bacterial and aseptic meningitis was equal (49%). Gender had not significant different between two groups (P =0.7). Bacterial group had a higher mean age than aseptic group (P=0.047). The level of IL-1 was not different between two groups(P =0.168). The level of IL-6,8 were significant different (P =0.030 &.047) respectively. Diagnostic values of IL-1 ,6 were 80.77%& 53.85% in bacterial group and 68% & 64% of aseptic group respectively that had not different (P=0.349&0.572). Diagnostic value of IL-8 was noted in the 80.77% of bacterial group and 28.00% of aseptic group that had significant different (P ˂0.001). Conclusion: Although determining the levels of IL-8 and IL-6 may beuseful in the differential diagnosis of meningitis, only IL-8 has suitable diagnostic value for distinction between bacterial and aseptic meningitis. Further studies have recommended.
Authors and Affiliations
Mohammad Reza Shokrollahi, Zahra Movahedi, Shima Javadinia, Azardokht Tabatabaei
Keywords
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- EP ID EP377177
- DOI 10.9790/0853-1707025861.
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