Assessment of ER, PR, p53 and HER2/neu Markers in Breast Carcinoma Patient
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 1
Abstract
Introduction: Breast cancer is reported as one of the most widespread cancers with more than 1,300,000 cases and 450,000 deaths each year worldwide. Hormone receptors and oncoproteins are used to determine prognosis and also predicts response to therapy in breast carcinoma patients. The present study was undertaken to find expression of ER, PR, p53 and HER2/neu in breast carcinoma. Material and Methods: The study was conducted among 50 cases of breast cancer patients. Specimens received as lumpectomy or mastectomy were subjected to immunohistochemistry for ER, PR, p53 and HER2/neu expression. Data so obtained was analysed using the SPSS Version 17 software and was expressed as percentage and number of respondents. Results: 18 cases (36%) revealed estrogen and progesterone receptor positivity, 6 cases (12%) revealed HER2/neu positivity, 52% cases showed combined ER and PR negativity and 26% cases were ER and PR positive. p53 positive cases comprised of 16 cases which were ER and PR negative. Conclusion: It was concluded that inversely proportional relation of p53 to ER PR expression was found. Thus, it can be considered as a marker for prognosis and disease free survival rate.
Authors and Affiliations
Manjot Kaur, Sanjay Piplani, Mridu Manjari, Vikrant Rai
Keywords
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- EP ID EP529893
- DOI 10.21276/ijmrp.2018.4.1.045
- Views 75
- Downloads 0
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