ASSESSMENT OF GASTRIC TUMOURS HIGHLIGHTING GASTROINTESTINAL STROMAL TUMOURS (GIST)- A STUDY OF 75 CASES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 19
Abstract
BACKGROUND Accurate diagnosis of gastric neoplasm is challenging and demands thorough histopathological evaluation. This study laid emphasis on GIST cases and their pattern of immunoreactivity with CD-117 and DOG-1, as on many occasions they are misdiagnosed. Aims and Objectives- To study histopathological features of various gastric tumours and compare the pattern of immunoreactivity of GIST cases with CD-117 vis-a-vis DOG-1. MATERIALS AND METHODS A study of patients with gastric tumours was conducted in a tertiary care hospital including careful examination of haematoxylin and eosin stained sections. Immunohistochemistry was performed for markers DOG-1 and CD-117 in cases diagnosed as GIST. Statistical analysis used- Tables and diagrams depicting data were prepared and analysed using SPSS version 20.0. Categorical variables were expressed as number of patients and percentage of patients and compared using Pearson’s Chi-Square test for independence of attributes. An alpha level of 5% has been taken, i.e. if any p-value is less than 0.05 it has been considered as significant. Settings and Design- It was a descriptive type of study, conducted for a period of two years. RESULTS Gastric tumours are common in age group of 51 - 60 years and in males. Among 75 cases, 54 cases were located at body of stomach. Predominantly, ulcerative growth pattern was observed. 16 cases were suspected to be GIST histopathologically, 44 moderately differentiated adenocarcinoma, 1 poorly differentiated neuroendocrine carcinoma, 5 infiltrating poorly differentiated adenocarcinoma and 9 well differentiated adenocarcinoma. Mostly advanced stage, pT2N1Mx (42.6%) cases were detected. 16 cases were differentially diagnosed as GIST. CONCLUSION Accurate diagnosis of gastric tumours demands thorough histopathological evaluation. DOG-1 has overall superior and crisply localised staining pattern than CD-117.
Authors and Affiliations
Pratyusha Bhattacharjee, Himansu Roy, Saumik Chakraborty
Keywords
Related Articles
- EP ID EP418218
- DOI 10.14260/jemds/2018/531
- Views 101
- Downloads 0
A STUDY OF ASSOCIATION BETWEEN BIRTH SEASONALITY, BIRTH ORDER AND SPACING IN SCHIZOPHRENIC PATIENTS
BACKGROUND Schizophrenia is a major psychiatric illness characterised mainly by abnormal thinking as well as changes in mood and perception. Western studies tell that Schizophrenics are born in monsoon contrary to Indian...
COMPARATIVE STUDY OF CYSTIC SWELLINGS OF SCROTUM IN ADULT PATIENTS
BACKGROUND Cystic swellings of the scrotum are common clinical entities that surgeons encounter in daily practice. Males of all ages are affected. Today, considerable heterogeneity exists in their treatment. This study s...
NON-OPERATIVE MANAGEMENT OF BLUNT HEPATIC AND/OR SPLENIC TRAUMA: A PROSPECTIVE STUDY
[b] PURPOSE[/b]: The incidence of blunt splenic and hepatic injuries are on a rise not only because of an increase in the overall incidence of Road Traffic Accidents but also due to more liberal use of radiolog...
SIGNIFICANCE OF PAP SMEAR IN DETECTING ABNORMALITIES OF CERVIX IN HIV-INFECTED WOMEN
BACKGROUND In India, around 22% of total reported AIDS cases and 30% of newer HIV infections are among women. Reproductive tract morbidities are common in HIV-infected women and they are 10 times more likely to have abno...
A STUDY OF HEARING EVALUATION FOR NEONATES WITH HYPERBILIRUBINEMIA USING OTOACOUSTIC EMISSION AND BRAIN STEM AUDITORY EVOKED RESPONSE
Jaundice is one of the most common problems occurring in newborns. Although most of jaundiced patients are normal; because of the bilirubin toxicity, high serum levels can lead to kernicterus. It is important to ide...