ASSESSMENT OF HAEMATOLOGICAL INDICES AND DNA PATTERN IN LEUKAEMIA PATIENTS KADUNA NIGERIA.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 1
Abstract
Leukaemia is the general name given to a group of cancers that develop in the bone marrow. It originates in developing blood cells that have undergone a malignant change leading to multiple uncontrolled malfunctioning cells. The end result include fatigue, weight loss, frequent infections and easy bleeding or bruising. The search for accurate information, data and solution is still a challenge to many developing countries like Nigeria. The study therefore reported the assessment of hematological parameters and DNA pattern in leukaemia patients attending hemato-onchologyclinic of Ahmadu Bello University Teaching Hospital (ABUTH) Zaria, Kaduna State Nigeria.500 suspected leukemia patients attending haemto-oncology clinic of ABUTH from March 2015 to October 2018 were included in the study. 3mL of the patients? blood were collected into EDTA bottles and analysed for full blood and differential count using automated blood counter and also thin blood smear were made, stained and examined for leukemic cells. The DNA were confirmed using polymerase chain reaction assay. Data were subjected to simple statistical analysis and results recorded. Full blood count and cytomophological method detected 30 (6%) prevalence of leukemia while PCR assay detect 28 (5.6%) prevalence in Kaduna State. The pattern of leukaemia DNA detected include 2.8% in Kaduna North district, 1.8% in Kaduna South District and 1% in Kaduna central district respectively. Decreased platelet count, packed cell volume and increased white blood cell count and presence of blasts and smudges cells were significant (P≤0.05).The molecular pattern of leukaemia and the prevalence were significant (P≤0.05) in Kaduna State, Nigeria. The presence of abnormal DNA and some hematological parameters is related to leukaemia infection in Kaduna state Nigeria.
Authors and Affiliations
Oledinma S, Emelike O. F, Akpulu S. P.
Keywords
Related Articles
- EP ID EP460274
- DOI 10.21474/IJAR01/8383
- Views 71
- Downloads 0
SELF-ADJUSTMENT STRATEGIES AMONG MEDICAL STUDENT IN THE TRANSITION FROM HIGH SCHOOL TO MEDICAL COLLAGE.
Amongst the time, self-adjustment is always being considered as a prominent factor in predicting the successfulness of students? high school?college transition process.The transition period can lead to stressful and anxi...
BIOCHEMICAL EVALUATION OF FIVE WILD FOOD PLANTS USED DURING WELDING PERIOD IN SOUTHERN MALI.
The fight against malnutrition has become one of the major concerns of many countries today. The most exposed are infants, older subjects and pregnant women. In sub-Saharan Africa, and particularly in Mali, studies have...
ROLE OF ECTOMYCORRHIZA IN FOREST ECOSYSTEMS: A REVIEW.
The fungal symbionts forming ectomycorrhizas benefit forest trees in a number of ways. The ectomycorrhizal fungi form as an important component of forest ecosystem. It contributes to a number of key ecosystem functions s...
SEA SURFACE TEMPERATURE INFLUENCED CORAL BLEACHING IN THE SALTWATER ISLANDOF GULF OF MANNAR, EASTERN SEA BOARD OF INDIA.
The Corals are symbiotic organisms which are very sensitive to different environmental variables and can tolerate up to their optimal limits. However SST is a key factor in terms of coral bleaching which can result in th...
IMPACT OF FINANCIAL SECTOR DEVELOPMENT ON ECONOMIC GROWTH IN RWANDA (2000-2015).
There have been heated debate empirical and theoretical debates as regards to the impact of financial sector on the growth of the economy in a country. While some studies concluded that financial sector drives economic g...