Assessment of Interleukin (8) in Type 2 Diabetes Mellitus
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 4
Abstract
<strong>Background: </strong>Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long- term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Type 2 diabetes (T2D) is characterized by a condition of systemic low-grade inflammation. IL-8 is an important member of the chemokine family of proinflammatory chemotactic cytokines. IL-8 was initially characterized as a potent chemoattractant of neutrophils and was later shown to also activate neutrophils. IL-8 is also known to be a potent promoter of angiogenesis. <strong>Objective: </strong>It was the Assessment of Interleukin (8) in Type 2 Diabetes Mellitus. <strong>Patients and Methods: </strong>Serum IL 8 level in Type 2 Diabetes Mellitus. 30 patients compared to 30 normal individuals were included in this study. <strong>Results: </strong>There was a highly statistical significant difference between all patients and control groups as regard serum IL 8 level (mean of serum IL 8 in patients and control groups were 69.9 ± 20.5 and 5.4 ± 3.3 respectively, p= < 0.001). <strong>Conclusion: </strong>Type 2 diabetes mellitus patients showed marked elevation of circulating IL-8 levels which identify subjects with worse inflammatory state and metabolic control and therefore it may be used as a marker for the rate of development of diabeteic complications.
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP584150
- DOI 10.12816/ejhm.2018.9298
- Views 97
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