Assessment of Lipid Peroxide and Lipid Fractions in Type 2 Diabetics with and Without Glycemic Control
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 4
Abstract
Diabetes mellitus is a Heterogenous and chronic metabolic disorder with a rapidly increasing prevalence globally. Oxidative stress may play a crucial role in pathophysiology of type 2 diabetes mellitus by increasing insulin resistance or impairing insulin secretion. To assess the lipid fractions and lipid peroxidation or MDA in type 2 diabetes mellitus cases with and without glycemic control and non-diabetics. A total 250 cases with type 2 diabetes mellitus and 250 age and sex matched control subjects with fasting glucose level ranging from 70-100mg were recruited. Blood serum was used to measure blood glucose levels, lipid fractions and lipid peroxidation. In uncontrolled diabetic patients fasting (224.36) and postprandial blood glucose levels (299.18) were highly significant than in controlled diabetic cases (121.03 in fasting, 188.88 in postprandial). Mean serum MDA levels are significantly higher in uncontrolled diabetic patients (5.12) as compared with controlled diabetic patients (4.49). Study suggests importance of assessing the markers of oxidative stress and antioxidant capacity along with the other routine investigations in diabetic patients for initiating antioxidant therapy and the need for novel methods to both prevent and treat this pandemic.
Authors and Affiliations
Dr. Patnam Giri, Dr. K. Ramesh
Keywords
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