Assessment of Mast Cell Density in primary CNS tumor in relation to the type and grade of tumor: A hospital-based study in Eastern India
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 9
Abstract
Introduction: Primary Central Nervous System (CNS) tumors constitute about 50% of all intracranial neoplasms. They originate from both mature and embryonic tissues. Mast Cells (MCs) play an important role in angiogenesis by secreting many angiogenic agents and regulates angiogenesis in many tumors and also in brain. They also play an important role in tumor progression, peritumoral edema formation and prognosis. Objective: This study has been conducted to know the Mast cell density (MCD) in various CNS Neoplasm and to study any correlation between MCD and Grade of tumors. Methods: All the surgically resected primary central nervous system tumor samples, those came to department of pathology from October 2016 to February 2018 was studied. Results: Mean MCD in meningioma is 23 cells/mm2. In case of secretory meningioma, MCD is significantly higher. Mean MCD of astrocytic and oligodendroglial tumors is 14 cells/mm2. Grade II tumors have high MCD compared to Grade III tumors. Mean MCD in schwannoma is 47 cells/mm2, range being 40 to 60 cells/mm2. Conclusion: In meningioma MCD is related to histological type of tumour. No association between grade and MCD has been observed. MCs are distributed randomly within tumor tissue. In astrocytic and oligodendroglial tumour MCD is higher in low grade tumours and in Schwannoma, MCD is higher.
Authors and Affiliations
Dr. Malay Sarkar
Keywords
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