Assessment of metabolic (Adiponectin, Leptin) and inflammatory markers (TNF-α, hs-CRP & IFN-γ) in Pulmonary Tuberculosis: Prospective Study
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 3
Abstract
Introduction: Tuberculosis (TB) remains one of the world’s deadliest communicable diseases. In 2013, an estimated 9.0 million people developed TB and 1.5 million died from the disease. TB is slowly declining each year and it is estimated that 37 million lives were saved between 2000 and 2013 through effective diagnosis and treatment. Objectives: The present study enrolled Pulmonary TB subjects with the objectives to estimate the levels of serum Adiponectin, Leptin, Tumour Necrosis Factor (TNF-α), high sensitivity-C Reactive Protein (hs-CRP) & Interferon- γ (IFN-γ) and to find correlation between Adiponectin, Leptin, Adiponectin/Leptin ratio, TNF-α, hs-CRP & IFN-γ in patients before and after treatment. Materials and Method: The study involved all the patients who were newly diagnosed as pulmonary tuberculosis in the OPD of Pulmonary Medicine of SGT Hospital. Venous blood samples of 50 patients of TB were collected before and after treatment with Anti TB drugs to estimate the levels of Adiponectin, Leptin, hs-CRP, INF–γ and TNF-α by commercially available kits in the Laboratory of Department of Biochemistry. Results: The levels of Adiponectin were higher in subjects diagnosed as new case sputum positive Pulmonary TB whereas the levels of Leptin and BMI measurements were low. Inflammatory markers like TNF-α, hs-CRP & IFN-γ were high in subjects before treatment and decreased after 6 months of Anti-Tubercular Treatment under DOTS Category 1. Conclusion: Adiponectin, Leptin, TNF-α, hs-CRP & IFN-γ can be labeled as potential biomarkers in the pathogenesis of Tuberculosis.
Authors and Affiliations
Neeraj Indora, Kapil Sharma, Busi Karunanand, DPS Sudan, Ashok Kumar Shah
Keywords
Related Articles
- EP ID EP297061
- DOI 10.18231/2394-6377.2017.0051
- Views 85
- Downloads 0
Serum neutrophil gelatinase-associated lipocalin as an early biomarker of acute kidney injury in subjects undergoing percutaneous transluminal coronary angiogram with normal EGFR
Introduction: Detecting AKI in a timely fashion with the current AKIN staging criteria is a challenge because the diagnosis of AKI is usually based on changes in serum creatinine (SCr) which is a poor marker of early ren...
Relationship between ischemia modified albumin and lipid profile in type 2 diabetes mellitus
Introduction Ischemia modified albumin IMA is new biomarker of oxidative stress and ischemia IMA being increased in Diabetes Mellitus has been described in many studies Diabetes Mellitus DM a metabolic disorder is charac...
Role of hemodialysis in management of patients of chronic kidney disease
Introduction: As kidney functions deteriorate, lipid profile abnormality begins. In kidney disease, more lipoprotein synthesis than its degradation results in dyslipidemia, which increases the risk of atherogenesis. The...
A study to assess the iron status of regular blood donors
Blood transfusions save lives and improve health. The general impact of blood donation on iron status has been studied since the late 1970’s. Iron deficiency anemia is a common finding in regular blood donors. According...
Assessment of metabolic (Adiponectin, Leptin) and inflammatory markers (TNF-α, hs-CRP & IFN-γ) in Pulmonary Tuberculosis: Prospective Study
Introduction: Tuberculosis (TB) remains one of the world’s deadliest communicable diseases. In 2013, an estimated 9.0 million people developed TB and 1.5 million died from the disease. TB is slowly declining each year an...