ASSESSMENT OF NEUROLOGICAL TOXICITY OF GOLD SPHERE AND ROD NANOPARTICLES USED AS ADJUVANT TO RIFT VALLEY FEVER VIRUS VACCINE (RVFV) AND RELATED PHYSIOLOGICAL CHANGES: IN VIVO STUDY
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 7
Abstract
Nanotechnology is a promising, rapidly growing discipline, and many research efforts have so far been focused on using nanoparticles as agents for targeted drug delivery. Although aluminum (Alum) salt is renowned as a vaccine adjuvant against Rift Valley Fever Virus (RVFV), gold nanoparticles (AuNPs) can be tested as alternative adjuvants to avoid associated alum disadvantages. This study was conducted using different molar concentrations of spherical and rod gold nanoparticles (AuNPs); 20 and 40 μM, those were subcutaneously injected into rats as an RVFV vaccine adjuvant to determine the subsequent blood and brain biochemistry changes in concomitant to neurotransmitters alterations. Interestingly, the present study indicated that the utilization of AuNPs adsorbed RVFV vaccine improved the blood and brain physiological changes as well as neurotransmitters disturbances resulted in the alum-adsorbed. Spherical AuNPs were much safer than rod NP with special attention for the NP concentration, therefore further detailed studies are required.
Authors and Affiliations
Dr. Rasha A. El Sayed
Keywords
Related Articles
- EP ID EP628854
- DOI -
- Views 151
- Downloads 0
DETERMINATION OF GLUCODE - 6 - PHOSPHATE DEHYDROGENASE LEVEL AMONG SUDANESE PATIENTS ON HEMODIALYSIS
Background: There is considerable evidence that patients on Hemodialysis are in continuous state of oxidative stress. Glucose-6-Phosphate Dehydrogenase (G6PD) is a cytoplasmic enzyme that protects erythrocytes against ox...
ASSOCIATION OF ANGIOTENSIN-CONVERTING ENZYME GENE INSERTION/ DELETION POLYMORPHISM WITH INCREASED RISK FOR CHRONIC LYMPHOCYTIC LEUKAEMIA
Background: Angiotensin converting enzyme (ACE) plays an important role in the stimulation bone marrow hematopoietic progenitors and umbilical cord blood cells proliferation and differentiation by converting angiotensino...
ETHNOMEDICINAL SURVEY OF MEDICINAL PLANTS FOUND IN KUNJAPURI HILL NOT MENTIONED IN NIGHANUS
An Ethno medicinal study under the title “ETHNOMEDICINAL SURVEY OF MEDICINAL PLANTS FOUND IN KUNJAPURI HILL NOT MENTIONED IN NIGHANUS” is immense importance with medical science. Now ethno medicine is considered as the b...
PREVALENCE OF AMPC β-LACTAMASE GENES AMONG CLINICAL ISOLATES OF ENTEROBACTER SPP. FROM SOME IRAQI HOSPITALS.
Background: Resistance to broad spectrum β-lactams mediated ESBLs and AmpC β-lactamase enzymes is a rising problem worldwide. Determination of their prevalence is essential to the creation of an effective antibiotics pol...
STUDIES ON PATHOGENESIS AND TREATMENT OF PREGNANCY TOXAEMIA IN SHEEP
Pregnancy toxaemia was induced in 15 sheep by dietary restriction and insulin administration. A clinical syndrome simulating naturally occurring pregnancy toxaemia was produced. Listlessness, ataxia, grinding of teeth, a...