ASSESSMENT OF REPRODUCTIVE TOXICITY AND GONADOTOXIC POTENTIAL<br /> OF N-METHYL-2-PYRROLIDONE IN MALE RATS
Journal Title: International Journal of Occupational Medicine and Environmental Health - Year 2008, Vol 21, Issue 1
Abstract
Objectives: N-methyl-2-pyrrolidone (NMP) is a solvent used in petrochemical, electric and electronic industries, and in the production of paint removers, pesticides and veterinary drugs. The substance exhibits slight acute toxicity, and moderate irritant, embryotoxic and teratogenic effects. The aim of the study was to assess NMP reproductive toxicity and gonadotoxicity in male rats. Material and Methods: The animals were exposed per os to NMP at daily doses of 0, 100, 300 and 1000 mg/kg. After 10 weeks of exposure, each male was mated with nonexposed female, then all the males were autopsied, and epididymis and testis were fi xed for pathomorphological examination. Viability and development of offspring was observed to 28 days postbirth. Results: NMP at 1000 mg/kg was found to produce male infertility and extensive damage to the seminiferous epithelium in the seminal tubules of the testis. When administered at 100 mg/kg or 300 mg/kg, it did not signifi cantly affect fertility or spermatogenesis. NMP exposure at 100 mg/kg did not infl uence either the viability or the development of their offspring in the fi rst month of life, while exposure at 300 mg/kg resulted in a signifi cantly lower viability of the offspring in the fi rst four days of life. Conclusion: This study has demonstrated that sub-chronic exposure of male rats to NMP at 1000 mg/kg/day produces gonadotoxic effect and brings about nfertility. Administration at lower doses of 100 and 300 mg/kg did not impair male fertility, but only the lowest dose of 100 mg/kg was found to have no infl uence on the prenatal development of the progeny.
Authors and Affiliations
KRYSTYNA SITAREK, JAN STETKIEWICZ
Keywords
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- EP ID EP96823
- DOI 10.2478/v10001-008-0006-z
- Views 111
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