Assessment of Serum Ferritin, Vitamin B12 and Folic Acid Level in Thalassemia
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 11
Abstract
Objective: To assess the levels of serum ferritin,vitamin B12,folic acid in thalassemic children. Material and Methods: This study was carried out in the Department of Biochemistry in SMS Medical college Jaipur. Thirty children with the confirmed diagnosis of thalassemia were enrolled in the study group and thirty healthy age and sex matched children were included in the control group. Estimation of serum ferritin, folic acid and vitamin B12 were done by ADVIA Centaur XP autoanalyzer by chemiluminescence immunoassay. Results: Study group showed a decrease in serum folic acid and vitamin B12 levels with mean value of 3.71 ±1.17 ng/mL and 163.6 ± 31.31 pg/mL respectively as compared to control group was 11.03±3.84 ng/mL and 439.33±127.6 pg/mL (p<0.001) whereas increased concentration of ferritin with mean value of 2144.7± 330.8 ng/mL in study group as compared to control group was 198.9 ± 66.9and was statistically highly significant (p<0.001). Conclusion: The present study found a significant decrease of vitamin B12, folic acid and increased ferritin in children with thalassemia. Biochemical screening of these parameters is of paramount importance in thalassemia patients in paediatric age group. Also, there is an absolute need for further studies to understand the mechanism of relationship between serum ferritin, Vitamin B12 and folic acid in these patients.
Authors and Affiliations
Dr Neha Sharma
Keywords
Related Articles
- EP ID EP521909
- DOI -
- Views 56
- Downloads 0
Gastroprotective and Antioxidant Effect of Gloriosa Superba on Indomethacin-Induced Gastric Ulcers in Rats
Gloriosa superba plant is well documented traditionally in Ayurvedic system of medicine and is used in treating many diseases. The present study was undertaken to evaluate the gastroprotective effect of Gloriosa superba...
Clinico-Serological profile of Acute Sporadic Viral Hepatitis in Kashimiri Adults: Hospital based Prospective Study
Background: There is no report on clinico-serological profile of acute viral hepatitis from the state of J & K since the discovery of hepatitis E and hepatitis C. Methods: A prospective hospital based study was conducted...
Evaluation of Carotid Intima Media Thickness as a Preclinical Atherosclerosis Marker in Diabetic Patients of North India
Objective: To evaluate carotid intima media thickness as a preclinical atherosclerosis marker in diabetic marker in diabetic patients. Method: The study was conducted in PG Department of Medicine in Cardiology Unit, SN M...
The Pattern of Microbial Keratitis in soft Contact Lens Wearers in a Tertiary Care Hospital in Eastern India
Background: Soft contact lenses are increasing in trend since a decade and are being used for both cosmetic and therapeutic purposes. Lack of compliance and poor hygiene towards lens care is one of the main causes associ...
To Study the Efficacy of Homoeopathy in Management of Cases of Benign Paroxysmal Positional Vertigo (BPPV)
Background: Dizziness is a common and often vexing symptom. Dizziness or Vertigo is a hallucination of the sense of equilibrium and movements, where the person feels that either his surroundings are going round him, or h...