Assessment of sIgA, IgG and IgM immunoglobulin levels in the saliva of children with type 1 diabetes
Journal Title: Journal of Stomatology (Czasopismo Stomatologiczne) - Year 2012, Vol 65, Issue 5
Abstract
Introduction. Testing the biochemical properties of saliva makes it possible to evaluate changes in the oral cavity and morphology of the salivary glands in patients with type 1 diabetes. Aim of the study. Assessing the influence of type 1 diabetes on the levels of sIgA, IgG and IgM in the saliva of children and adolescents. Material and methods. Unstimulated saliva obtained from 60 patients aged 7-17 years with controlled type 1 diabetes. The control group consisted of 30 healthy children corresponding to the experimental group in gender and age. The levels of sIgA, IgG and IgM were assessed. The levels of sIgA, IgG and IgM immunoglobulins were determined by means of radial immunodiffusion. Also determined were the concentrations of immunoglobulins (mg/mL) and the amounts of immunoglobulin secreted into the oral cavity within a time unit, i.e. output (one-minute secretion). Results. The results showed significant differences in immunological specificity of saliva in children suffering from type 1 diabetes, as compared with a group of healthy children. Conclusion. Type 1 diabetes affects the levels of sIgA, IgG and IgM immunoglobulins in saliva.
Authors and Affiliations
Anna Zalewska, Anna Kuźmiuk, Małgorzata Knaś, Danuta Waszkiel
Keywords
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