Assessment of the quality of fresh frozen plasma and refrozen thawed fresh frozen plasma – A prospective study at a tertiary care teaching hospital in Chennai
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 2
Abstract
Introduction FFP contains the labile as well as stable components of the coagulation fibrinolytic and complement systems The use of plasma and its products has increased manifold over the four decades In blood transfusion service the primary goal of quality is transfusion of safe unit of bloodAim of the Study To ensure that the prepared fresh frozen plasma FFP consistently met the requirements for quality and to find out the potency and possible extension of shelf life of fresh frozen plasma once thawed and refrozen within stipulated period Materials and Methods 66 units of FFP prepared by Platelet Rich Plasma PRP method were divided into two groups Group 1 comprised of 33 samples which were tested on 0 day last week of 12th month and last week of 18th month Group 2 comprised of remaining 33 units which were tested on 0 day thawed and tested on 1st week of 12th month and were again refrozen within 12 hours of thawing Later the refrozen units were again retested on the last week of 12th month All the FFP units were evaluated as per the DGHS GuidelinesResults Group 1 The quality of fresh frozen plasma stored at 30OC for 12 months adhered to quality parameters but on extended storage period 30OC for 18 months showed noncompliance to the standardized quality control Group 2 Refrozen thawed plasma complied with all quality parameters Discussion Fibrinogen and Factor VIII levels which were representative of stable and labile factors respectively were within normal limits in both the study groups when stored at standardized temperature and time but showed noncompliance to the standardized quality control at extended time Refrozen thawed plasma retained all coagulation factors These findings were in concordance with the DGHS Standards and various other studies Conclusion Fresh Frozen Plasma should be used judiciously and if thawed plasma is not used for some reasons it should not be discarded The thawed FFP can be refrozen and added up to the inventory and hence useful to the societyKeywords Good manufacturing practice Fresh frozen plasma Platelet rich plasma Thawed and refrozen fresh frozen plasmanbsp
Authors and Affiliations
D. Umesh, Arumugam P
Keywords
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- EP ID EP475502
- DOI 10.18231/2394-6792.2018.0053
- Views 41
- Downloads 0
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