Assessment of Total Antioxidant Capacity and Lipid Profile among Pregnant Women Attending Ante Natal Clinic in University of Calabar
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2016, Vol 2, Issue 4
Abstract
Abstract: Normal pregnancy is associated withchanges in lipid metabolism and high metabolic demand accompanied by elevated tissue oxygen requirements and increased oxidative stress. The present study was carried outto evaluate lipid profile and total antioxidant status in pregnant women at UCTH, Calabar, Nigeria. Serum lipid profile and total antioxidant capacity were estimated in ninety (90) apparently healthy pregnant women aged between 18 and 40 years and thirty non-pregnant controls. Test subjects were divided into three trimesters based on their gestational age. Blood samples were collected from all recruited participants; total antioxidant capacity and lipid profile were analyzed using colorimetric methods. Lipid profile parameters and TAC varied among the various trimesters of pregnancy and in the controls (P<0.05). Controls had significantly higher mean values of TAC compared to the 2nd and 3rd-trimester group (P<0.05). The first trimesters group had higher TAC and lower mean total cholesterol and LDL-C compared to the 2nd and 3rd-trimester group (P<0.05). Third-trimester group recorded higher mean value of TG compared to the 1st trimester and control group (P<0.05). Pregnancy and increasing gestational age may be associated with decreased total antioxidant capacity and increased TC, LDL-C and TG. Keywords: Total antioxidant capacity, pregnancy, total cholesterol, triglycerides, low-density lipoprotein cholesterol.
Authors and Affiliations
Ogar Francis Awusha, Agu Chidozie Elochukwu, Inaku Kenneth Ogar, Nsonwu Augusta, Etukudo Maisie
Keywords
Related Articles
- EP ID EP388325
- DOI -
- Views 98
- Downloads 0
Development and Validation of Stability Indicating Rp-Hplc Method for the Simultaneous Estimation of Sofosbuvir and DaclatasvirDihydrochloride in Bulk Drug and Pharmaceutical Dosage Form
Abstract:A new stability indicating RP-HPLC method was developed and validated for the simultaneous estimation of Sofosbuvir and Daclatasvir in pharmaceutical dosage form and bulk drug. The optimized conditions for the s...
Determination of three active compounds of methanolic extract ofSchisandrachinensis by RP-HPLC
Abstract: To establish a method fordetermination of contents of schizandrolA，deoxyschisandrin and schisandrin B in Schisandrachinensis( Turcz. )Baill.. An RP-HPLC method was developed. A KromasilC18 column (250 mm×4.6...
Biowaiver studies of seven generic brands of allopurinol (100 mg) tablets available in Sudanese market
Abstract:Allopurinol is the drug of choice in the treatment of gout It reduces the concentration of urates and uric acid in tissues, plasma and urine, while increasing the concentration of xanthine and hypoxanthine.The p...
Community-Based Correlation Study of Early Indicators of Complications amongst Asymptomatic Type-2 Diabetes Patients
Abstract:This cross-sectional, community-based study was conducted in the area of the Urban Health Training Centre of a municipal medical college, located about 30 kms from Mumbai (India). The participants were 57 female...
A Novel Spectrofluorimetric Method for the Estimation of Gefitinib in Raw Material and Pharmaceutical Dosage Form
Abstract:A simple and sensitive spectrofluorimetric method has been developed for the estimation of Gefitinib in pure and pharmaceutical dosage form. Gefitinib exhibits maximum fluorescence intensity in ethanol and Beer’...