Association between butyrylcholinesterase activity and low-grade systemic inflammation[sub][/sub]
Journal Title: Annals of Hepatology - Year 2012, Vol 11, Issue 3
Abstract
Background. Pro-inflammatory cytokine production is directly inhibited by acetylcholine (ACh), and a relationship between total circulating ACh hydrolytic capacity and inflammatory reactions has been previously reported. Butyrylcholinesterase (BChE) is the major ACh hydrolyzing enzyme in plasma, and the aim of our study was to evaluate its association with low-grade systemic inflammation. Material and methods. A total of 4,077 patients clinically managed in the Cardiology, Hypertension, and Digestive Medicine Units were included in our study. Three subclinical chronic inflammatory degrees were established in accordance with the high-sensitivity C-reactive protein (hsCRP) concentrations proposed, for low (< 1 mg/L), average (1-3mg/L), and high (> 3-10 mg/L) cardiovascular disease risk estimation. Results. In male patients with subclinical chronic inflammation and hsCRP concentrations < 1 mg/L, a significant positive correlation was observed between BChE and hsCRP (p < 0.02); however, for hsCRP concentrations > 3 mg/L, the correlation between these variables in both sexes becomes significantly negative (p < 0.001), as in patients with acute inflammation (hsCRP > 10 mg/L). In all cases significant positive correlations were obtained between theBChE activities and albumin concentrations (p < 0.001). Conclusions. The liver production of BChE and albumin occurs in a coupled fashion, and these biochemical variables may be considered as negative inflammatory reactants, whose serum levels are inversely associated with the increasing degree of subclinical inflammation.
Authors and Affiliations
Natalia Lampón, Esperanza Hermida-Cadahia, Alberto Riveiro, J. Tutor
Keywords
Related Articles
- EP ID EP78148
- DOI -
- Views 156
- Downloads 0
What constitutes liver failure after transjugular intrahepatic portosystemic shunt creation? A proposed definition and grading system
Background and rationale for the study. There is currently no definition of post-transjugular intrahepatic portosystemic shunt(TIPS) liver failure (PTLF), which constitutes a barrier to standardization of TIPS results r...
Clinical Characteristics and Complications of Pediatric Liver Biopsy: A Single Centre Experience
Introduction. Percutaneous liver biopsy (LB) is the gold standard method for evaluation and management of patients with liver disease. The purpose of this study was to characterize pediatric patients undergoing LB at Bri...
Evidence that estrogen receptors play a limited role in mediating enhanced recovery of bile flow in female rats in the acute phase of liver ischemia reperfusion injury
[b]Introduction[/b]. Female patients exhibit better survival and less hepatic damage from ischemia reperfusion (IR) injury following surgery. However, the effects of sex and estrogens on liver function in the acute phase...
Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19
Background and rationale for the study. FGF19/15 is a gut-derived hormone presumably governing bile acid (BA) synthesis and gallbladder (GB) refilling. FGF19 mRNA is present in human GB cholangiocytes (hGBECs); however,...
Acetylcholine receptor antibody positive generalized Myasthenia gravis in association with Primary Biliary Cirrhos
Primary Biliary Cirrhosis and Myasthenia Gravis are both autoimmune conditions, however, there are only rare case reports of their association. This is a case report of acetylcholine receptor antibody positive generalize...