Association between FGFR4 gene polymorphism and high-risk HPV infection cervical cancer
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2017, Vol 10, Issue 7
Abstract
Objectives: To discuss the association between FGFR4 gene polymorphism rs351855 (Glu388Aly) and the susceptibility and chemotherapeutic effect of cervical cancer infected by high-risk type HPV. Methods: A total of 162 patients with high-risk HPV cervical cancer and 162 healthy women were collected and the genotypes of the FGFR4 rs351855 locus were detected. The genotype distributions in the two groups were compared. The cervical cancer patients were divided into four groups which namely good therapeutic effect group and bad therapeutic effect, recurrence or metastasis and no recurrence or metastasis group respectively, and the risks of different genotype on the curative effect and prognosis were analyzed by Logistic regression. The survival time of patients with different genotypes was compared. Results: Therewas no statistic difference in FGFR4 rs351855 genotype distribution between the patients group and control group (P>0.05),amongwhich the risk of chemotherapy failure on GA + AA patients was 3.257 times as much as that of the GG patients, and the risk of recurrence or metastasis of GA + AA patients was 2.783 times as much as that of the GG patients. For AA patients, the risk of chemotherapy failure and the risk of relapse and metastasis are 3.833 and 3.406 times, respectively, as much as that of the GG patients. The overall survival ofGAandAApatientswas shorter than that of theGGpatients, and significant difference was found (c2 = 7.098, P = 0.029). The difference in overall survival between GA+AApatients andGGpatients was almost statistically significant (c2 = 3.634, P=0.057). Conclusions: The FGFR4 rs351855 polymorphism is not associated with the susceptibility of high-risk HPV cervical cancer, but patients with gene A was at higher risk of unfavorable chemotherapy prognosis compared with patients with GG.
Authors and Affiliations
Ya-Ping Li, Yan Yu
Keywords
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- EP ID EP279284
- DOI 10.1016/j.apjtm.2017.07.008
- Views 83
- Downloads 0
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