Association between NFKB1 (-94 ins/del ATTG) gene polymorphism and Multiple Sclerosis in the Turkish Population
Journal Title: Advance Research Journal of Multidisciplinary Discoveries - Year 2018, Vol 29, Issue 29
Abstract
Multiple sclerosis (MS) is a chronic inflammatory and an autoimmune disease affecting the central nervous system (CNS). It is suggested that the NFκB signaling pathway is involved in MS development and that NFκB is a key transcription factor involved in the regulation of immune response, apoptosis and pathology of autoimmune diseases. A recently discovered promoter polymorphism in NFKB1 (-94 insertion/deletion ATTG) gene may be associated with MS development.The purpose of this study was to reveal the relationship between NFKB1 -94 insertion/deletion ATTG polymorphism and MS in a Turkish population. A total of 379 patients with MS and 214 healthy individuals from the Turkish population were investigated. The promoter region of NFKB1 gene was amplified DNAs from patients and controls by specific primers and their PCR products were digested by suitable enzyme.NFKB1 (-94 ins/del ATTG) genotype distribution showed a strong association with MS (p=0.0001), and the NFKB1 (-94 ins /del ATTG) allele frequency also showed a significant association to the disease (p = 0.011).Our results suggested that the NFKB1 -94 ins/del ATTG gene promoter polymorphism is associated with MS in the Turkish population.
Authors and Affiliations
Arman A, Erzaim N, Isik N, Saridal M, Hoscan AY, List EO
Keywords
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