Association between overweight and obesity in schoolchildren with rs9939609 polymorphism (FTO) and family history for obesity
Journal Title: Jornal de Pediatria - Year 2016, Vol 92, Issue 5
Abstract
Objective To determine the association between overweight/obesity in schoolchildren with FTO rs9939609 polymorphism (fatmass and obesity associated) and family history of obesity. Methods Cross-sectional study comprising a sample of 406 children aged 7–17 years in a city in southern Brazil. Overweight/obesity in schoolchildren was assessed by body mass index (BMI), and family history of obesity was self-reported by parents. Polymorphism genotyping was performed by real time PCR (polymerase chain reaction). The association between the nutritional status of schoolchildren with the presence of family obesity, stratified by polymorphism genotypes (AA [at-risk for obesity], AT, and TT), was assessed by prevalence ratio values (PR) through Poisson regression. Results Among schoolchildren with the AA genotype, 57.4% had overweight/obesity; the percentage was lower for the AT and TT genotypes (33.1% and 28.9%, respectively). Overweight/obesity in schoolchildren was associated with a family history of obesity, especially among children with the AA genotype. The prevalence was higher among those with an obese mother (PR: 1.28; p<0.001), obese maternal or paternal grandmother (PR: 1.22; p=0.047), and obese paternal grandfather (PR: 1.32; p<0.001). Conclusions There is an association between the AA genotype of rs9939609 polymorphism and BMI among schoolchildren. The association between overweight/obesity in schoolchildren with a family history of obesity was found mainly among students with the AA genotype.
Authors and Affiliations
Cézane Priscila Reuter
Prevalence and causes of congenital microcephaly in the absence of a Zika virus outbreak in southern Brazil
Objective The aim of this study was to identify the causes of congenital microcephaly in Rio Grande do Sul, a state in southern Brazil, where no ZIKV outbreak was detected, from December 2015 to December 2016, which was...
Influence of socioeconomic and psychological factors in glycemic control in young children with type 1 diabetes mellitus
Objective To evaluate the influence of socioeconomic and psychological factors on glycemic control in young children with type 1 diabetes mellitus. Methods This was a cross-sectional study assessing prepubertal children...
Quality of life, school backpack weight, and nonspecific low back pain in children and adolescents
Objectives To describe the degree of disability, anthropometric variables, quality of life (QoL), and school backpack weight in boys and girls aged 11-17 years. The differences in QoL between those who did or did not rep...
Dietary transition difficulties in preterm infants: critical literature review
Objective To analyze the scientific literature on dietary changes in preterm children during the first years of life. Data source The PubMed database was used for article selection. The texts were analyzed according to...
Temporal and spatial evolution of maternal and neonatal mortality rates in Brazil, 1997–2012
Objective Maternal and neonatal mortality are important public health issues in low-income countries. This study evaluated spatial and temporal maternal and neonatal mortality trends in Brazil between 1997 and 2012. Met...