Association between seminal plasma neopterin and oxidative stress in male infertility: A case-control study
Journal Title: International Journal of Reproductive BioMedicine - Year 2018, Vol 16, Issue 2
Abstract
Background: Neopterin is a significant and sensitive marker in estimating the activity of cellular immune system. Oxidative stress plays a role in the etiology of male infertility. Increased reactive oxygen species is accompanied with increase in neopterin level. Hence neopterin may be involved in male infertility. Objective: The objective of this case-control study was to determine neopterin level in idiopathic infertile and normospermic men; furthermore, to identify its relationship with oxidative stress markers including total oxidant, malondialdehyde, sperm DNA fragmentation, and total antioxidant capacity of seminal plasma. Materials and Methods: Forty seven infertile and forty three normospermic males were selected according to WHO criteria. Their semen and blood samples were taken; subsequently, the levels of neopterin, total oxidant, total antioxidant, malondialdehyde, and sperm DNA fragmentation were measured. Results: The levels of neopterin, total oxidant, and malondialdehyde in seminal plasma of infertile males were significantly higher than those of normospermic group (p=0.038, 0.018, and 0.028, respectively). Furthermore, sperm DNA fragmentation in infertile men was higher than that of control group (p<0.001). Moreover, total antioxidant capacity of seminal plasma in infertile males was significantly lower than that of normospermic subjects (p=0.002). No significant difference was observed in serum neopterin, total oxidant, and malondialdehyde between the infertile and normospermic groups. Conclusion: The significant inverse correlation between seminal plasma neopterin and total antioxidant in the infertile males supports a possible role of neopterin in male infertility. Neopterin can be suggested as a marker in monitoring and diagnosis of idiopathic male infertility.
Authors and Affiliations
Tayebeh Ghiasvand, Mohammad Taghi Goodarzi, Gholamreza Shafiee, Alireza Zamani, Jamshid Karimi, Marzieh Ghorbani, Iraj Amiri
Keywords
Related Articles
- EP ID EP283312
- DOI 10.29252/ijrm.16.2.93
- Views 97
- Downloads 0
Low birth weight may increase body fat mass in adult women with polycystic ovarian syndrome
Background: Women engaged with polycystic ovarian syndrome (PCOS), as the commonest endocrine disorder, are known to have a specific type of adiposity. Birth weight is among different contributors reported to be responsi...
Effectiveness of infertility counseling on pregnancy rate in infertile patients undergoing assisted reproductive technologies: A systematic review and meta-analysis
Background: Psychological interventions such as counseling for infertile patients seem to increase pregnancy rate. Objective: The aim of this systematic review and meta-analysis was to examine if counseling improves preg...
The prevalence of hypovitaminosis D and its risk factors in pregnant women and their newborns in the Middle East: A systematic review
Background: Pregnant women and newborns are at risk for vitamin D deficiency (VDD). Also, poor health outcomes for pregnant women with VDD are reported in the published literature. Objective: The aim of this systematic r...
Mini-laparotomic Colpotomy for a Cervicovaginal Leiomyoma: Preservation of hymenal integrity
Background: Leiomyomas are the most common benign tumors of the uterus. Removal of the prolapsed pedunculated submucous myoma represents a distinct entity. Evaluation and treatment of such cases may need intervention via...
Predicting factors of medical treatment success with single dose methotrexate in tubal ectopic pregnancy: a retrospective study
Background: Nowadays, The first step in treatment of ectopic pregnancy (EP) is medical treatment. Medical treatment with methotrexate (MTX) for EP is safe and effective method without the risks associated with the surgic...