Association between Testosterone and Prostate Cancer among SudanesePatients in Khartoum State
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 4
Abstract
Background: Prostate is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals. It considers differ among species anatomically chemically and physiologically. Prostate cancer also known as carcinoma of the prostate, is the development of cancer in the prostate, a gland in the male reproductive system .Most prostate cancers are slow growing; however, some grow relatively quickly. Testosterone in the presence of a slow-growing prostate cancer is assumed to increase its growth rate. However, the association between testosterone supplementation and the development of prostate cancer is unproven. Aim: To measure testosterone level in prostate cancer patients and to correlate between testosterone level and PSA level with the duration of therapy. Material and Methods: The present study was is analytical cross-sectional study carried out during May to July 2016, at Al Zaiem Al Azhari University, Medical Laboratories Sciences College, and Clinical pathology department. A total one hundred individuals were enrolled in this study, and classified into two groups, 50 prostate cancer patients as case group and 50 healthy individuals as control group. Enzyme immunoassay analysis for testosterone level .The data of prostate cancer types, age, and sex of patients were collected from clinic records. Results: The results were expressed as (mean ± SD), study was found that the level of testosterone in patient with a mean of (3.8/14) it was lower than the control mean of (5.4/9) and also the study found that the level of PSA in patients group with a mean of (28.3/1) is significantly increase when compared to healthy individuals with a mean of (0.8/2) and there was significant difference between two group, the study was found that there was significant correlation between testosterone level and duration of therapy, in the other hand PSA showed no significant association with the duration of therapy. Conclusions: Finally the study concluded that significant reduction of testosterone level in patient with prostate cancer when compare to healthy individuals and there was significant correlation between testosterone level and duration of therapy.
Authors and Affiliations
Mohammed Muawia Hassan Mohammed, Ahmed Mohammed Ahmed, ,Abdelgadir Eltom, Amna O. M. Elzein3 .
Keywords
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- EP ID EP390398
- DOI 10.9790/3008-1204085457
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