Association between VDR Gene Polymorphisms (<i>rs 1544410</i>, <i>rs 7975232</i>, <i>rs 2228570</i>, <i>rs 731236</i> and <i>rs 11568820</i>) and Susceptibility to Breast Cancer in a Sample of Southeastern Iranian Population
Journal Title: International Journal of Cancer Management - Year 2017, Vol 10, Issue 3
Abstract
Background Vitamin D receptor (VDR) is a key nuclear receptor that is associated with the risk and progression of breast cancer (BC). Objectives The present study investigated the <i>Fok1</i>, <i>Bsm1</i>, <i>Taq1</i> and <i>Cdx2</i> polymorphisms in the VDR gene and susceptibility to BC in a sample of Southeastern Iranian population. Methods This case-control study was conducted on 180 women with BC and 178 age-matched healthy women. RFLP-PCR method was used for analysis of <i>Bsm1</i> (<i>rs 1544410</i>), <i>Apa1</i> (<i>rs 7975232</i>), <i>Fok1</i> (<i>rs 2228570</i>) and <i>Taq1</i> (<i>rs 731236</i>) and also TETRA-ARMS method for <i>Cdx2</i> (<i>rs 11568820</i>). Results No significant correlation was found between polymorphisms of <i>Taq1</i>, <i>Fok1</i> and Apa1 with BC, but was for <i>Bsm1</i> (odds ratio (OR) = 3.452, 95% CI 1.769 - 6.738; P < 0.001). Also, there was a significant correlation between the case and control groups for <i>Cdx2</i> (OR = 3.720, 95% CI 2.224 - 6.225; P < 0.001) and allele A in <i>Cdx2</i> had just significant correlation with BC. Conclusions The present study findings showed that there were significant correlations between <i>Bsm1</i> and <i>Cdx2</i> polymorphisms with BC in women of Sistan and Baluchestan Province (southeastern Iran). Also, signals of <i>Rs1544410-Bsm1</i> and <i>Rs11568820-Cdx2</i> positions were difference with routes of estrogen and progesterone per person and they probably act independently.
Authors and Affiliations
Seyed Mehdi Hashemi, Narges Arbabi, Mohammad Hashemi, Mohammad Ali Mashhadi, Abolghasem Allahyari, Masoud Sadeghi
Keywords
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- EP ID EP237330
- DOI 10.5812/ijcm.8807
- Views 66
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