Association of Albumin to Creatinine Ratio with Cardiovascular Risk Markers and Determination of Their Cut off Points in Type 2 Diabetic Nephropathy Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Urine albumin to creatinine ratio (ACR) is found to be the most promising indicator for confirmation of nephropathy in type 2 diabetes mellitus patients. It is also known that the increased excretion of urine microalbumin is associated with high risk of cardiovascular diseases. The present study was aimed to attain the association of BMI, FBG, HbA1c, cardiovascular markers, urine creatinine & urine microalbumin, and also to find out the cut off points of these markers for the prediction of cardiovascular disease in type 2 diabetic nephropathy patients. We included 110 type 2 diabetic nephropathy patients and 110 healthy age and gender matched healthy controls. The value of BMI, and levels of FBG, triglycerides, VLDL cholesterol, urine creatinine and urine microalbumin were found to be positively associated and HDL cholesterol was negatively associated with ACR in type 2 diabetic nephropathy patients. Further, ROC curve analysis of BMI, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol and VLDL cholesterol gave the cut off values of >24.3, >187.2, >143.1, ≤42.7, >119.9 and >37.2, respectively with significant area under the ROC curve, highest sensitivity and highest specificity. From these results we conclude that the ACR apart from its function as an indicator of nephropathy can also serve as an indicator of cardiovascular risk in type 2 diabetic patients. These cut off values can be used for prediction of cardiovascular disease risk in type 2 diabetic nephropathy patients.
Authors and Affiliations
Bhoite GM, Bulakh PM, Kuvalekar AA, Momin AA
Keywords
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- EP ID EP597475
- DOI 10.9790/0853-1605066367.
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