Association of Angiotensin-I-Converting Enzyme (ACE) Insertion/Deletion Gene Polymorphism with End Stage Renal Disease in Egyptian Patients
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 8
Abstract
Angiotensin-I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been associated with the genetic susceptibility to end stage renal disease (ESRD) in different populations. ACE DD genotype and D allele are associated with ESRD as risk factors in several studies. In this study, we investigated the association between ACE I/D gene polymorphism and ESRD in the Egyptian patients. Frequencies of D allele and DD genotype were significantly increased, while frequencies of I allele and ID genotype were significantly decreased in the ESRD patients when compared with the control subjects (P = .012, OR = 1.82, 95% CI = 1.139-2.915 for DD) and (P = .018, OR = 1.6, 95% CI = 1.082-2.33 for D). In conclusion, ACE DD genotype and D allele are associated with ESRD as risk factors for ESRD in the Egyptian population.
Authors and Affiliations
A. F. AbdeL-Aziz, Afaf EL-Saeed, Khaled EL-Dahshan, Basma AL-Sayed Ebead
Keywords
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- EP ID EP348655
- DOI 10.9734/BJMMR/2014/4463
- Views 61
- Downloads 0
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