ASSOCIATION OF APOLIPOPROTEIN B WITH CORONARY ARTERY DISEASE IN MEN
Journal Title: Stanley Medical Journal - Year 2016, Vol 3, Issue 3
Abstract
Aim: To evaluate the association of non conventional risk factor for atherosclerosis, serum ApoB levels in patients with and without CAD in comparison to conventional lipid parameters. Methods: A casecontrol study on 100 subjects male subjects in the mean age of 51 yrs, with and without Coronary Artery Disease(CAD), confirmed by coronary angiogram was conducted and the levels of serum ApoB, Total cholesterol, serum triglycerides(TGL) , serum Low density lipoprotein(LDL)and Serum High Density Lipoprotein(HDL) were estimated. Pearson’s correlation was done to find the association of ApoB and conventional lipid parameters with development of CAD. Results: Patients with CAD had significantly high serum total cholesterol(193 + 46), LDL-C (126 + 43) ,HDL(36 + 7) and Apo B(108 + 24) levels compared to control subjects. However, serum TGL (155 + 71) level did not show a significant difference between two groups. Pearson’s correlation coefficient shows that Apo B levels show moderate association with Total cholesterol & LDL levels in the CAD group. The data was recorded and analysed on SPSS system. The results of cases and controls were compared by student t-test. Apo B was correlated with lipid parameters by Pearson’s correlation. A value of P<0.05 was considered significant. Conclusion: Apo B is a better predictor of cardiovascular risk compared to conventional lipid profile.
Authors and Affiliations
Mahalakshmi R, Shanthi R, Vijayalakshmi M
Keywords
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