Association of hexachlorobenzene in the serum and adipose tissue with type 2 diabetes: a systematic review and meta-analysis and meta-regression
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 9
Abstract
The prevalence of metabolic disease type 2 diabetes is increasing. Numerous studies have to take into consideration in addition to the factors such as low mobility, nutrition and inheritance, environmental factors such as hexachlorobenzene in creation of type 2 diabetes. Therefore, it was tried in this study to obtain an exact result regarding the association of hexachlorobenzene with type 2 diabetes by doing a systematic review and metaanalysis of the cross-sectional and prospective studies which were received till 2 March 2016. After searching in the databases SID, Irandoc, Pubmed, Scopus, Ovid, Embase, ISI and Cochrane, 10 studies with 19 subgroups were considered in final assessment. Geometric mean concentration of Hexachlorobenzene was 12.7 ng/ml and 64.77 ng/g lipids in serum and adipose tissues, respectively. The heterogeneity index of I2:25.95% (I2<50%) and t2:0.075 were low and hence fixed model was used for meta-analysis of studies' results. The Pearson correlation coefficient between concentrations of hexachlorobenzene in serum and adipose tissue with the odds ratio of type 2 diabetes were R2:0.27, P value=0.57 and R2:0.25, P value=0.18, respectively. The highest and lowest odds ratios of type 2 diabetes was [OR:6.2 (0.6-68.1)] and [OR:0.99 (0.3-2.6)], respectively. Overall, the odds ratio for type 2 diabetes induced to hexachlorobenzene was OR:2.33 (1.82-2.74) P value<0.001. Results of this study supported the role of hexachlorobenzene significantly as an environmental risk factor in type 2 diabetes (P<0.001).
Authors and Affiliations
Zahra Mosallanejad| Food and Cosmetic Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran, Raheb Ghorbani| Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran, Gea Oliveri Conti| Environmental and Food Hygiene Laboratories (LIAA), ‘G.F. Ingrassia’ Department, Hygiene and Public Health, University of Catania, Catania, Italy, Yadolah Fakhri| Studends Research Office, Department of Environmental Health Engineering, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Nazak Amanidaz| Environmental Health Research Center, Golstan University of Medical Sciences, Golstan, Iran, Yahya Zandsalimi| Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran, Bigard Moradi| Department of Health Public, Kermanshah University of Medical Sciences, Kermanshah, Iran, Leila Rasouli Amirhajeloo| Department of Environmental Health Engineering, School of Public Health, Qom University of Medical Sciences, Qom, Iran, Hassan Keramati| Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran Corresponding Email: Hkramatee@gmail.com
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