Association of higher circulatory levels of homocysteine with additional risk factors in CAD patients
Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Coronary artery disease (CAD) is a leading cause of mortality worldwide. In developing countries it has been observed that stressful life style is mainly associated with CAD. Inflammatory environment has been produced due to formation of various oxidant and proinflammatory molecules which keeps inflammatory pathways active. Aim: The present study aimed to compare the circulatory levels of homocysteine in CAD patients and normal controls. Methodology: The study protocol was approved by institutional ethical committee. Total 198 subjects (107 CAD patients and 91 age sex matched controls) have been included in the present study. Blood sugar, lipid profile levels were estimated in both CAD patients and controls. Results: High levels of homocysteine have been observed in CAD subjects [17.41± (10.27)] compared to the controls [7.38± (3.67)]. No significant difference have been observed in LDL levels in controls and CAD respectively [105.32(±33.66)/ 108.93(±41.51)]. However HDL levels were found to be significantly lower in CAD patients than controls [38.71 (±13.73)/ 44.94(±11.34). Additional risk factors like Type 2 diabetes (DM) and Hypertension (HTN) in CAD group has shown high homocysteine than CAD patients without any additional risk factors. Conclusion: Hyperhomocysteinemia is found to be associated with CAD patients. It was also observed that increased pattern of homocysteine levels in CAD patients were associated with additional risk factors like DM and HTN factors.
Authors and Affiliations
Thomas James, Vidhate Deepali Amarsinh, Murarka Arpith, Dhadialia Simranjit Kaur, Shakya Prashant Sing, Chavan Aarati
Keywords
Related Articles
- EP ID EP198790
- DOI -
- Views 91
- Downloads 0
Changes in neck structure due to compression of neck in medicolegal autopsy – A retrospective study
Deaths due to compression of neck constitutes a major portion of unnatural deaths in day to day medico legal practice. The cases of such death, if analyzed are found to be either due to suicidal compression or homicidal...
The comparative study between the efficacy of high dose of acyclovir and erythromycin on pityriasis rosea
Pityriasis Rosea or PR is a commonly encountered papulosquamous disorder, which is self limiting in nature. Researchers believe of its infective origin, either bacterial or viral. AIM: To compare the treatment efficacy w...
Alexander disease - A case report
Alexander disease is rare leucodystrophy with three recognized clinical forms- Infantile Juvenile and Adult. Alexander disease show specific radiological and histopathological features.
Incidence, risk factors and prognostic factors of acute renal failure in patients admitted to trauma care unit
Background: Acute renal failure (ARF) is a frequent and fatal complication after trauma. A better comprehension of the clinical spectrum of a disease is needed to identify potential areas of intervention. The aim of the...
A study of prevalence of hypertension in adolescents at urban area of Muzzafarpur, Bihar
Background: The World Health Organization (WHO) describes overweight obesity and hypertension as one of today’s most important public health problems, which is escalating as a global epidemic. Aims and Objectives: To Stu...