ASSOCIATION OF HISTORY AND CLINICAL PARAMETERS IN LEPTOSPIROSIS AND THEIR ASSOCIATION WITH SEVERITY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 31
Abstract
BACKGROUND Leptospirosis is an important cause of morbidity and mortality in Kerala and severe leptospirosis has been reported in almost 60% of Leptospira infected individuals. Overlapping symptomatology with other diseases makes misdiagnosis very common though adequate hydration and use of appropriate antibiotics reduce morbidity and mortality. This study is conducted to evaluate the association of history, symptoms and clinical examination findings with leptospirosis and its severity. MATERIALS AND METHODS The present descriptive study enrolled 84 participants over 18 years with confirmed leptospirosis. Participants with preexisting renal and hepatic impairment, chronic obstructive pulmonary disease and bronchial asthma were excluded. Institutional ethics committee approved the study and written informed consent was obtained from all participants. Data was collected in separate case record forms and was analysed using R®. All parameters are expressed as categorical variables and tests of significance were Chi-square test, Fischer’s exact test. p<0.05 was considered statistically significant. RESULTS 71.4% participants were males. Most common symptoms were fever (98.8%), headache (98.8%) and myalgia (73.8%). 84.5% participants had less than 7 days inpatient stay. Most common examination finding was icterus (23.8%). 70.2% (n=59) of the study participants had severe leptospirosis. Significant association was observed between severity of leptospirosis and age (p=0.02), icterus (p=0.001) and duration of inpatient stay (p=0.04). CONCLUSION Young males were predominantly involved highlighting occupational exposure. Commonest symptoms were fever, headache and myalgia indicating the risk of misdiagnosis. Commonest examination finding was icterus (22%). 70% had severe leptospirosis and significant association was observed between age, icterus, duration of inpatient stay with severity of leptospirosis. Further studies on larger samples are required to assess the exact association of these parameters.
Authors and Affiliations
Elizabeth Jacob, Sinu R. V
Keywords
Related Articles
- EP ID EP570129
- DOI 10.18410/jebmh/2018/475
- Views 68
- Downloads 0
PREVALENCE OF DEPRESSIVE DISORDER AND ITS TREATMENT AMONG PATIENTS WITH CHRONIC PAIN- A CROSS SECTIONAL STUDY
BACKGROUND Depression coexisting with chronic pain can influence the course and prognosis of chronic pain due to any aetiology. Till the psychopathology remains unveiled and treated, rehabilitation process in chronic pai...
STUDY OF RISK FACTORS IN ABDOMINAL WOUND DEHISCENCE FOLLOWING EMERGENCY LAPAROTOMY
BACKGROUND Abdominal wound dehiscence is a common complication following emergency laparotomy. Wound dehiscence often reflects an error of judgement on the part of surgeon and the elimination of postoperative wound dehis...
THERAPEUTIC IMPLICATIONS OF GENETIC RISK VARIANTS FOR CORONARY ARTERY DISEASE
BACKGROUND This review covers therapeutic implication of genetic risk variant responsible for coronary artery disease by utilising the highdensity single-nucleotide microarrays to screen the entire human genome. The sequ...
EVALUATION OF THE HIGH-SENSITIVITY C-REACTIVE PROTEIN IN YOUNG OBESE WOMEN WITH PCOS
BACKGROUND The Polycystic Ovarian Syndrome (PCOS) is one of the most common reproductive disorder in young women affecting 5-10% of population. PCOS women are at increased risk of developing metabolic syndrome, type 2 di...
CLINICAL AND ANGIOGRAPHIC PROFILE OF CALCIFIC VS. NON-CALCIFIC CORONARY LESIONS
BACKGROUND We wanted to assess the clinical and angiographic characteristics associated with coronary lesion calcification as compared to non-calcified lesions in those with significant angiographic stenosis. METHODS Thi...