Association of hypertriglyceridemic-waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN-III study
Journal Title: Jornal de Pediatria - Year 2016, Vol 92, Issue 5
Abstract
Objective This study aims to investigate the role of metabolic syndrome (MetS) and the hypertriglyceridemic-waist (HW) phenotype in determining cardiometabolic risk factors and elevated liver enzymes in a national sample of Iranian pediatric population. Method This nationwide study was conducted in the framework of the third survey of a surveillance program. Students, aged 10–18 years, were recruited from 27 provinces in Iran. The prevalence of cardiometabolic risk factors was compared in students with and without HW and MetS. The association of HW with different cardiometabolic risk factors was determined. Results The mean age of studied population was 14.73±2.41 years. Prevalence of HW and MetS was 3.3% and 4%, respectively. Sixty-nine (71.1%) participants with HW had MetS. The prevalence of obesity, elevated systolic blood pressure, hypercholesterolemia, and elevated alanine aminotransaminase (ALT) was significantly higher in subjects with HW phenotype and MetS than in their peers (p<0.05). A significant association was observed between HW and elevated levels of cholesterol and ALT, as well as between obesity and low HDL-C (p<0.05). Conclusions The current findings serve as complementary evidence to previous studies, which have been mainly conducted among adults, suggesting that the HW phenotype is associated with cardiometabolic risk factors, especially with elevated cholesterol and ALT. The authors propose that, in primary care settings and in large epidemiological studies, the measurement of all MetS components can be replaced by studying HW as a screening tool for identifying children at high risk for cardiometabolic disorders.
Authors and Affiliations
Silva Hovsepian
Keywords
Related Articles
- EP ID EP512245
- DOI 10.1016/j.jped.2015.12.009
- Views 55
- Downloads 0
Maternal depression and anxiety and fetal-neonatal growth
Objective Maternal depression and anxiety have been found to negatively affect fetal and neonatal growth. However, the independent effects of maternal depression and anxiety on fetal-neonatal growth outcomes and trajecto...
Daily meal frequency and associated variables in children and adolescents
Objective To investigate the frequency distribution of daily meals and its relation to demographic, socioeconomic, behavioral, anthropometric and biochemical factors in children and adolescents. Methods This was a cross...
Genetic determinants and stroke in children with sickle cell disease
Objective To verify genetic determinants associated with stroke in children with sickle cell disease (SCD). Methods Prospective cohort with 110 children submitted to neonatal screening by the Neonatal Screening Program,...
The association of sleep and late-night cell phone use among adolescents
Objective This study aims to assess the relationship of late-night cell phone use with sleep duration and quality in a sample of Iranian adolescents. Methods The study population consisted of 2400 adolescents, aged 12–1...
A method for the assessment of facial hedonic reactions in newborns
Objective This study describes a quantitative and qualitative methodology to assess hedonic responses to sweet stimulus in healthy newborns. Methods A descriptive, cross-sectional, observational study, with healthy newb...