Association of plasma glucose, serum lipid profile, and liver enzymes with non-alcoholic fatty liver disease - A case–control study
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2019, Vol 8, Issue 9
Abstract
Background: The prevalence and complications of nonalcoholic fatty liver disease (NAFLD) have increased dramatically over the past decade. The pandemic of lifestyle disorders and their role in the development of NAFLD encourage studies in this aspect. Aims and Objectives: To evaluate the association of laboratory parameters such as plasma glucose (fasting, postprandial, and glycated hemoglobin), serum lipid profile, and liver enzymes with NAFLD. Materials and Methods: Our case–control study enrolled 150 participants [81 cases (sonological evidence of fatty infiltration of liver) and 79 controls] in a period of 2 years. All laboratory investigations were done in the central laboratory of the institution using appropriately standardized techniques. Institutional ethics committee approved this study and written informed consent was obtained from all study participants. Data were analyzed using free software R®, nominal variables were compared using independent sample t-test and Mann–Whitney U-test; categorical variables were compared using Chi-square test. P < 0.05 was considered statistically significant. Results: Higher number of male participants (56.3%) enrolled in the study. Significant difference in total cholesterol (TC) (P < 0.001), low-density lipoprotein (LDL) (P < 0.001), triglycerides (TG) (P < 0.001), alanine aminotransferase (ALT) (P = 0.002), TC/high-density lipoprotein (HDL) (P = 0.001), and TG/ HDL (P < 0.001) was observed between cases and controls. Significant association with NAFLD was observed for TG (P = 0.001), TC (P < 0.001), dyslipidemia (P = 0.02), aaspartate aminotransferase (AST) (P = 0.03), and ALT (P < 0.001). Conclusion: High prevalence of prediabetes and diabetes were observed among participants undergoing voluntary health checkup. Significant difference in TC, LDL, TG, TC/HDL, TG/HDL, and ALT was observed between cases and controls. Significant association with NAFLD was observed for TG, TC, dyslipidemia, AST and ALT.
Authors and Affiliations
Nirmal George, Abhilash Kannan, Kala S N, Abhaya Prasannarajan
Keywords
Related Articles
- EP ID EP496095
- DOI 10.5455/njppp.2018.8.06211322062018
- Views 64
- Downloads 0
Prevalence of prehypertension and its association with levels of stress and anxiety among students of various disciplines in Chennai - A cross-sectional study
Background: Assessment of the prevalence of prehypertension among the student population and its association with risk factors such as stress and anxiety is very essential to plan preventive programs. This cross-sectiona...
Immediate benefits of “Om” chanting on blood pressure and pulse rate in uncomplicated moderate hypertensive subjects
Background: Chronic stress plays major role in the development of hypertension (HTN) in young-aged and middle-aged adults in the present scenario of fast lifestyle. Such patients can be treated better by stress reduction...
Lifestyle risk factors for coronary artery disease among young male patients of urban and rural Dakshina Kannada - A cross-sectional study
Background: There has been an increase in morbidity and mortality due to coronary artery disease (CAD) in developing countries due to multiple risk factors. India’s concern is not only the high burden of CAD but also its...
In vitro antibacterial potential of chitosan and its derivatives on pathogenic enterobacteriaceae
Background: Chitosan (deacetylated chitin) and its derivatives, which are known to possess pharmaceutical and biomedical properties, have gained considerable attention in the biomedical field. The nontoxic, biocom...
A cross-sectional analytical study on the influence of age in the precision and accuracy of non-invasive blood pressure recording compared to invasive intra-arterial pressure recording
Background: Even after 115 years after the invention of Riva-Rocci Sphygmomanometer, the technique which shows the maximal accuracy of blood pressure (BP) measurement remains elusive. Currently, non-invasive BP (NIBP) re...