Association of Serum 25-Hydroxyvitamin-D Level with Carotid Artery Intima Media Thickness in Indian Patients of Type-2 Diabetes Mellitus
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 10
Abstract
Abstract:Vitamin D deficiency is common in Indian population which has a high prevalence of cardiovascular disease. We aimed to find the association of serum 25-hydroxyvitamin D(25-OH-D) level with Carotid artery Intima Media Thickness(CIMT)-a marker of subclinical atherosclerosis, in type-2 diabetics, a high risk group for cardiovascular disease. Type-2 Diabetes Mellitus patients attending to OPD of PGIMER & Dr. RML Hospital, New Delhi, were enrolled in the study. Winter serum 25-OH-D levels were measured by enzyme immunoassay using IDS 25-OH-D EIA kit. Vitamin D deficiency was defined as serum 25-OH-D level less than 50 nmol/L.CIMT was measured by B-mode ultrasonography, on Philips HD 11 machine with transducer L12-3 MHz. CIMT >0.8 mm was considered abnormal. Multivariate linear regression analysis was used to identify independent predictors of increased CIMT.100 patients were studied (55 men and 45 women)with mean age 52.9 ± 11.1 years and mean duration of diabetes 9.2 ± 6.2 years. The prevalence of vitamin D deficiency was 71% in study group. Increased CIMT was seen in 25% patients. Serum 25-OH-D level was associated inversely with CIMT on univariate regression analysis (r2=0.61, p-value<0.001). On multivariate regression analysis, low serum 25-OH-D level was found to be independent predictor of increased CIMT (p-value<0.001) even after adjustment for risk factors showing association with CIMT on univariate analysis (p value<0.005,relaxedupto p value<0.2) which included serum 25-OH-D level, sex, smoking, HbA1c and HDL cholesterol. This regression model accounted for 65%(r2=0.65) of total variance in CIMT. Serum 25-OH-D level has an independent inverse association with Carotid Intima Media Thickness-a marker of subclinical atherosclerosis. Keywords:Serum 25-OH-D, CIMT, Type 2 Diabetes, Hypovitaminosis D.
Authors and Affiliations
Chetan P Mulatkar, Rajnish Singh, Himanshu Mahapatra, Anil Taneja, Neera Sharma
Keywords
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