Association of trace element with bone metabolism in inflammatory bowel disease patients
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2018, Vol 25, Issue 3
Abstract
Bonedemineralization is a significant problem in Inflammatory Bowel Disease. Contributing factors including inadequate nutrition, corticosteroid, and decreased physical activity .Trace elements play an important role in the growth development and maintenance of bones .The aim of our study was to assess the relationship between the serum Zinc level and the bone Mineral indexes in Inflammatory Bowel Disease patients. Forty two newly diagnosed patients of Inflammatory Bowel Disease and forty healthy Controls of both gender ranging in age from 19-50 years were included in the study. Fasting blood samples were processed for following biochemical parameters– Serum Calcium, Phosphorus, Vitamin D, Parathyroid Hormone and Zinc. The subjects were evaluated for Bone Mineral Density (g/cm2) using Dual Energy X-rayAbsorptiometryscan and T score was calculated to assess Osteoporosis. Student’s unpaired t-test, one way ANOVA and Pearson correlation tests were used for statistical analysis .Inflammatory Bowel Disease patients had significantly lower Bone Mineral Density than the Controls. Bone Mineral Density values were not different between the subtypes Crohn’s Disease and Ulcerative Colitis. Though Ulcerative Colitis and Crohn’s Disease patients had significantly lower Bone Mineral Density than the Controls. Low Zinc level was observed in 50% of Osteopenic and 80% of Osteoporotic subjects. Zinc level was positively correlated with Bone Mineral Density(r=0.24) and Vitamin D (r=0.25) . Patients with Inflammatory Bowel Disease are more prone to develop metabolic bone disease. Along with other nutrients supplement Zinc should be added to prevent bone loss.
Authors and Affiliations
Anjali 1, Vijaylaxmi Nangliya, Dharamveer Yadav, Amit Soni, Sandeep Nijhawan, Sandhya Mishra
Keywords
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