Atherogenic Index of Plasma: A Marker for Undetectable Dyslipidaemia among Lichen Planus Patients
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 1
Abstract
ABSTRACT Introduction: Lichen Planus (LP) is a chronic inflammatory cutaneous disease. Some studies investigated its association with Dyslipidaemia as a main contributing factor for cardiovascular insults. Atherogenic Index of Plasma (AIP) is a strong factor for suspecting that risk. Aim: To investigate lipid profile and calculate AIP in LP patients to early detect atherogenic Dyslipidaemia, if present. Materials and Methods: This case-control study investigated 40 LP patients and 20 age, gender and body mass index (BMI) matched healthy volunteers. Lipid profile of all subjects was evaluated. AIP was estimated as Log {Triglycerides (TGs)/ High Density Lipoprotein-Cholesterol (HDL-C)} and accordingly, patients were categorised into high, medium and low cardiovascular risk patients. Results: Dyslipidaemia was detected in 47.5% of patients, while all control subjects had normal lipid profile (p<0.001). High Total Cholesterol (TC) and Low Density Lipoprotein-Cholesterol (LDL-C) mean values were significantly associated with LP patients as compared to controls (p<0.001 for both), while no significant differences regarding HDL-C and TG levels have been detected. AIP was significantly elevated in LP patients compared to controls (p=0.002). Most of the patients (72.5%) have high cardiovascular risk versus 30% of controls (p=0.004). About one-third of the high cardiovascular risk patients (31.9%) had no dyslipidemia. High risk patients tend to be of older age with no significant differences regarding gender or disease duration. Conclusion: AIP is a good predictor of cardiovascular risk in LP patients even in presence of normal lipid profile and should be evaluated in every case to permit earlier management.
Authors and Affiliations
Noha Mohammed Dawoud, Ola Ahmed Bakry, Mohammed Abd el Moneim Shoeib, Nora Abd El Satar Dawood
Keywords
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- EP ID EP556261
- DOI 10.7860/JCDR/2019/39639.12496
- Views 120
- Downloads 0
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