Attenuation of Monosodium Glutamate-Induced Hepatic and Testicular Toxicity in Albino Rats by Annona Muricata Linn. (Annonaceae) Leaf Extract
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
Introduction and aim of the work: The protective effects of ANNONA MURICATA LINN leaf extract (Graviola) against orally administered Monosodium glutamate (MSG) for 4 weeks induced hepatic and testicular toxicity on male albino rats were examined. Methods: The rats were divided into 4 groups • Group 1: Served as negative control: The rats were daily orally administrated with ml of distilled water for 4 weeks. • Group 2: Served as control Graviola group: The rats were orally administrated with Graviola leaf extract dissolved in distilled water at a dose level of 100 mg/kg body weight for 4 weeks. • Group 3: Served as control mono-sodium glutamate group (MSG): The rats were orally administrated with monosodium glutamate dissolved in distilled water at a dose level of 4mg/kg b.wt, for 4 weeks. • Group 4: served as treatment group: The rats were orally administrated with monosodium glutamate dissolved in distilled water at a dose level of 4mg/kg b.wt, for 4 weeks, then followed by treatment with Graviola leaf extract dissolved in distilled water at a dose level of 100 mg/kg body weight for another 4 successive weeks. Liver and testes were examined for alterations in BCL-2 and Caspase-3 protein expression and histopathology. Results: MSG up-regulated BCL-2 and Caspase-3 expression in LIVER AND TESTES where Caspase-3 expression was significantly increased (p<0.05) and BCL-2 expression was significantly (P<0.05) decreased but ANNONA MURICATA LINN leaf extract (Graviola) administration as a therapeutic treatment almost normalized the histological and immunohisto chemical alterations. Conclusion: present findings confirmed the protective and therapeutic effects of ANNONA MURICATA LINN leaf extract (Graviola) on MSG induced alteration in liver and testes in male albino rats.
Authors and Affiliations
1 Eman Mohammed Mohammed Abd-Ella, Abd-Elkarim Mohammed Abd-Lateif Mohammed
Evaluation of Rubella, Toxoplasma gondii, and cytomegalovirus seroprevalences in women with miscarriage as adverse reproductive outcome in current pregnancy in ALBIYDA /LIBYA
This study aimed to determine the seroprevalence of Toxoplasma gondii, rubella, and cytomegalovirus among 71 pregnant women with age range from 19 to 45, who had mischarge as adverse reproductive outcome in current pregn...
Physico-chemical and Nutritional Characteristics, and Antimicrobial Activity of Oil Palm Syrup, Raffia Palm Syrup and Honey
The physico-chemical characteristics and antimicrobial activity of oil palm syrup, raffia palm syrup and honey were studied. The materials contained mainly carbohydrate (64.76-68.79%) and water (28.05- 31.50). They exhib...
Evaluation of Phytochemical and Antioxidative properties of Rosa kordesii Petal Extracts
Plant extracts have been reported to have contributed to the increase of nutritional values which are important to the human health. Investigations were carried out to evaluate the phytochemicals content and antioxidant...
Cytoprotective And Anti Ulcer Activities of The Ethanolic Leaf Extract of Irvingia Gabonensis on Aspirin-Induced Ulcer
This study evaluated the gastroprotective and hepatoprotective effects of ethanolic leaf extract of Irvingia gabonensis on aspirin-induced ulcer in albino rats. The animals were grouped into 5 groups of 5 rats each with...
GC-MS Analysis of Phytochemical Compounds of Normal and Leaf Galls of Madhuca longifolia (Koenig) j.f.Macb.
Plant galls are manifestations of growth and of differentiation induced on a plant by animal or plant parasite. Madhuca longifolia (Koenig) J.F. Macb.is widely distributed in tropical mixed deciduous forests in India in...