Autologous bone marrow cells for avascular necrosis femoral head
Journal Title: IP International Journal of Orthopaedic Rheumatology - Year 2016, Vol 2, Issue 2
Abstract
Avascular necrosis (AVN) of the femoral head can be a devastating progressive disease most commonly affecting patients younger than 40 years of age. Although the exact pathophysiology of AVN has yet to be elucidated, the disease is characterized by a vascular insult to the blood supply of the femoral head, which can lead to collapse of the femoral head and subsequent degenerative changes. If AVN is diagnosed in the early stages of the disease, it may be possible to attempt surgical procedures which preserve the hip joint, including decompression of the femoral head augmented with concentrated bone marrow. The use of autologous stem cells has shown promise in halting the progression of AVN of the femoral head, and subsequently preventing young patients from undergoing total hip arthroplasty. We studied five patients of stage 2 osteonecrosis of femoral head with core decompression and insertion of autologous mononuclear cells with aseptic precautions. There was significant reduction in pain and joint symptoms with no further radiological progression in 12 months of follow up.
Authors and Affiliations
Venus Khanna, Parul Tripathi, Prabhu Mishra, Rohit Kulkarni, Manish Khanna
Keywords
Related Articles
- EP ID EP242902
- DOI -
- Views 82
- Downloads 0
Innovation of a Novel Therapeutic Modality for Treatment of Osteoarthritis of Knee with Autologous Adipose Derived Stromal Vascular Fraction (AD-SVF)
Background: Adipose tissue derived stromal vascular fraction is crude heterogeneous mixture of different cell population. SVF possess potential to translate into oesteogenic and chondrogenic lineage. We designed a pilot...
Von Willebrand disease - broadening our vision: a pediatric case report with dental considerations
Von Willebrand disease is an autosomal inherited bleeding disorder caused due to the quantitative or qualitative defects of a multimeric glycoprotein, the Von Willebrand factor (VWF). VWF is a multi-adhesive protein that...
JAK inhibitors: Evolving therapies in rheumatoid arthritis
In rheumatoid arthritis there has been a paradigm shift from controlling symptoms to controlling the disease progress with abrogation of inflammation Achieving this remission or very low disease activity has become incre...
Extra-Articular Proximal Tibia fractures: Proximal tibia plate versus intramedullary nailing
Introduction Extraarticular promixal tibial fracture make up to around 101 of all shaft tibia fractures which are most commonly due to high velocity injury Both conservative and operative management options are available...
Comparative evaluation of the efficacy of locally delivered 0.1% curcumin irrigation, meswak irrigation and 0.2% CHX irrigation in management Chronic periodontitis patients
Introduction: Ayurvedic medicines like turmeric possess anti-inflammatory, anti-oxidant, and anti-microbial properties. This study was carried out using the purest form of turmeric and meswak to test their anti-plaque an...