Autologous leukocyte-poor platelet-rich plasma injection in the treatment of knee osteoarthritis: short-term clinical effect analysis
Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 10
Abstract
Objective To investigate short-term clinical efficacy of autologous leukocyte-poor platelet-rich plasma(LP-PRP) treatment of knee osteoarthritis(KOA). Methods 85 cases of patients with Keligren Lawrence grade Ⅰ-Ⅲ knee osteoarthritis in Peking University First Hospital Taiyuan Hospital (Taiyuan Central Hospital) from 2022 to 2023 were collected for autologous LP-PRP collection and quality assessment using a blood component separator, and all patients were treated with autologous LP-PRP. The degree and function of knee pain were assessed by visual analog scale(VAS) and knee arthritis index scale(WOMAC) at 1, 3 and 6 months after injection. Knee MRI was performed after 6 months of treatment, and the MRI imaging changes before and after treatment were compared. Different influencing factors in the treatment results were grouped and analyzed, mainly including platelet concentration in LP-PRP and K-L grading of knee joint. According to the platelet concentration in LP-PRP, it was divided into three grades, which are low concentration[(<800)×109/L], medium concentration[(800-1 000)×109/L], and high concentration[(>1 000)×109/L]; According to the K-L grade of the knee joint, the severity of knee osteoarthritis was divided into three grades: Ⅰ、Ⅱ、Ⅲ. Results The VAS and WOMAC scores at 1, 3 and 6 months after LP-PRP treatment were significantly lower than those before treatment, and the difference was statistically significant (P<0.05). There was a statistically significant difference in the therapeutic effect of different levels of platelet concentration, and when the platelet concentration was more than 1 000×109/L, the significant effect was the most obvious(P<0.05). The therapeutic effect of different levels of platelet concentration was statistically significant(P<0.05). MRI showed that the articular cartilage signal was significantly improved after treatment. Conclusion Autologous LP-PRP injection into knee cavity for the treatment of KOA has a good short-term clinical effect in relieving knee pain.
Authors and Affiliations
Lei YANG, Doudou JING, Mingxi LIU, Zhenye GUO, Binai YANG, Shuzhong LIN, Demei ZHANG, Fengyan GUO, Jin LIU
Keywords
Related Articles
- EP ID EP749833
- DOI 10.13303/j.cjbt.issn.1004-549x.2024.10.004
- Views 26
- Downloads 0
Frequency survey of blood group PP1PK in Chinese Lahu Population
Objective To investigate the frequency of P1PK and GLOB blood group in Chinese Lahu population and their genetic status, so as to provide data support for the safety of blood transfusion and give advice and transfusion g...
Implementation of points-based household registration policy for voluntary blood donors in Nanjing
Objective To analyze the implementation effect of points-based household registration policy for blood donors in Nanjing, so as to provide reference for other provinces and cities to develop incentive policies for blood...
Analysis of high risk factors and establishment of risk score model for postpartum massive blood transfusion
Objective To screen the risk factors of severe postpartum hemorrhage that can be found at 32 weeks of pregnancy through univariate and multivariate analysis and establish the risk prediction diagram. Methods A retrospect...
Research on a new microtubule technology of reagent bursting for crossmatching test
Objective To develop a quick and accurate crossmatching test technology without the power equipment and additional reagents before blood transfusion, so as to improve the timeliness and safety of blood transfusion treatm...
Antibody identification and analysis of 80 children with positive platelet antibody in initial screening
Objective To explore the distribution and types of platelet antibodies in children with positive platelet antibody in initial screening. Methods Blood samples of 80 pediatric patients who applied for platelet transfusion...