Autonomic cardiovascular regulation in Parkinson’s disease by head-up tilt test - A cross-sectional study
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2019, Vol 8, Issue 9
Abstract
Background: Autonomic failure is an integral component of Parkinson’s disease (PD), and orthostatic hypotension (OH) is commonly observed in advanced cases of PD. OH may be the result of underlying cardiovascular autonomic dysfunction or adverse effect of antiparkinsonian drugs. Patients may be asymptomatic during the early stage of disease but may have underlying cardiovascular dysautonomia which becomes obvious on stress. Most of the earlier studies used morphological and functional methods to evaluate cardiovascular autonomic control but were unable to evaluate during dynamic conditions. Aims and Objectives: The aim of the study was to evaluate cardiovascular autonomic disturbances in patients with PD using head-up tilt table test (HUTT). The objective of the study was to compare the spectral profile of heart rate variability (HRV) and blood pressure (BP) to orthostatic challenges using HUTT in patients with PD with healthy individuals. Materials and Methods: In this cross-sectional study, we have recorded continuous lead II ECG along with BP every 2 min in patients with PD and control group during HUTT for 10 min in supine, 45 min in 70° tilt and again 10 min in supine position which were later analyzed using Biopac software for HRV. Results: Symptoms indicating autonomic nervous system dysfunction were present in 65% (20) patients with PD. Postural dizziness was present in 20% (6) patients. After 5 min of tilt-up, increase in HR in patients with PD was lower than in controls. There was no significant change in diastolic BP (DBP) on tilting-up in patients with PD while DBP significantly increased in controls on tilting-up from73 ± 9 mm Hg to 80±11 mm Hg (P < 0.00001). The low frequency (LF) was not significantly changed in patients with PD,and it increased significantly in controls from 3.05 (2.28 to 4.70) ms2 to 3.73 (2.69– 5.03) ms2 . There was decrease low frequency/high frequency (LF/HF) in patients with PD, but the change was not significant, and there was a significant increase in LF/HF ratio from 3.43 (3.15 to 4.02) to 5.01 (4.39–5.74) in control group (P < 0.00001). Conclusions: Patients with PD suffered from symptoms of autonomic dysfunction and had cardiovascular autonomic dysfunction which becomes obvious only during stress. This will help clinicians to identify the patients of PD with cardiovascular autonomic dysfunction at an early stage and modify the treatment accordingly to prevent frequent falls
Authors and Affiliations
Raksha Jaipurkar, Latika Mohan, Rajesh Tomar
Keywords
Related Articles
- EP ID EP496015
- DOI 10.5455/njppp.2018.8.0413615052018
- Views 81
- Downloads 0
A study on the prevalence of childhood obesity in private schools of Kurnool city population
Background: Excessive energy intake and reduced physical activity are worldwide accepted contributing factors for childhood obesity. Aims and Objectives: The objective of this study was to study the prevalence of childho...
Knowledge, practice, and attitude toward adverse drug reaction reporting among interns at a tertiary health care centre
Background: Adverse drug reactions (ADRs) are an important public health problem in terms of mortality, morbidity as well as costs. However, studies worldwide have shown gross under-reporting with a rate of just 6–10%. K...
Evaluation of summative assessment pattern for undergraduate pharmacology practical examination
Background: The Medical Council of India (MCI) has stated the minimum standards in its regulations for the quality of Medical Education in India. It is observed that assessment of medical students, though an important as...
Combined effects of pranayama and suryanamaskar on dynamic spirometric values in normal young subject
Background: Good health and freedom from disease is the best achievement of life. Tremendous progress has been made in the field of medicine in recent years. Modern medicine as well as yoga has scientific basis an...
Dietary habits and menarche among young female medical students
Background: Menstrual cycle is a physiological change that occurs in female subjects. The first menstruation of women is called menarche. The developmental status of a pubertal female can be assessed using this vi...