AZADIRACHTIN, CARDIOFOLIOSIDE AND KUTKIN CAN BE VITAL PHYTOCHEMICALS FOR THE MODULATION OF SECRETASE ENZYMES FOR THE TREATMENT OF ALZHEIMER’S: AN IN-SILICO ANALYSIS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 4
Abstract
Objective:The aim of this study was to screen for active components from medicinal plants of Uttarakhand that has potential for a therapeutic agent for AD by targetingthe secretase enzyme using in-silico approach. Methods: We used iGEMDOCK for in-silicodocking experiments to screen for active components from medicinal plant, can modulate secretase enzyme. Binding energies for active component from 112 medicinal plants were analyzed. Results: Our in-silicoanalysis suggests that Cardiofolioside, Azadirachtin, Berberine and Kutkin can best possible candidates for modulation of secretase enzyme and thus hold potential to help patients with AD. The results obtained clearly suggeststhat these active components from plants herbal have the ability to modulate α and β-secretase either as an activator of α-secretase or as an inhibitor of β-secretase when compared with known standard drug. Conclusion: Cardiofolioside, Azadirachtin, Berberine and Kutkin can acts as a modulator for secretase enzymes and these phytochemicals can be exploited for their potential to that of AD.
Authors and Affiliations
Prashant Anthwal
Keywords
Related Articles
- EP ID EP605761
- DOI -
- Views 88
- Downloads 0
IN VITRO ANTIMICROBIAL ACTIVITY AND MOLECULAR CHARACTERIZATION OF BACILLUS AMYLOLIQUEFACIENS ISOLATED FROM SIMILIPAL BIOSPHERE RESERVE, ODISHA, INDIA
Objective: The purpose of our study was to isolate and identify the bacteriocinogenic strain exhibiting broad range antimicrobial activity and to analyze the effect of different culturing conditions on the production of...
PROTECTIVE EFFECT OF SYNTHETIC ANTIOXIDANTS AND ETHANOLIC EXTRACT OF BACOPA MONNIERI AGAINST LEAD TOXICITY INDUCED METABOLIC DYSFUNCTIONS IN MICE BRAIN AND LIVER HOMOGENATES: AN IN VITRO APPROACH
Objective: The main objective of the present study was to investigate the ameliorative potential of synthetic antioxidants mixture comprising N-acetyl cysteine, ascorbic acid, tocopheryl acetate, and thiamine as micronut...
Synthesis and anti–microbial activity of 1,2,3–triazole tethered nitroguiacol ethers
Nitro aromatic/nitrophenols have been widely distributed in nature and are mostly isolated from marine microorganisms and had shown a broad spectrum of anti–microbial activities against a wide range of microbial pathog...
SYNTHESIS OF SOME NOVEL (E)-METHYL 2,4-DIMETHYL-5-(3-OXO-3-PHENYLPROP-1-EN-1- YL)-1H-PYRROLE-3-CARBOXYLATE DERIVATIVES AS ANTIMICROBIAL AGENT
Objective: The objective of the present study was to synthesize a series of some novel (E)-methyl 2,4-dimethyl-5-(3-oxo-3-phenylprop-1-en-1-yl)-1H-pyrrole-3-carboxylate derivatives and to evaluate it’s in vitro antimicro...
ESTIMATION OF CARDIAC SURGERY RESULTS
Objective: Estimation of cardiac surgery results after median sternal incision.Methods: This work contains the results of surgical treatment of 220 patients who had cardiac surgeries performed by means of the median ster...