B-Cell Targets to Treat Antibody-Mediated Rejection in Transplantation
Journal Title: International Journal of Transplantation Research and Medicine - Year 2016, Vol 2, Issue 2
Abstract
Abstract: Antibody-mediated rejection (AMR) in allograft transplantation can be defined with a rapid increase in the levels of specific serological parameters after organ transplantation, presence of donor specific antibodies (DSAs) against human leukocyte antigen (HLA) molecules, blood group (ABO) antigens and/or endothelial cell antigens (e.g. MICA, ECA, Vimentin, or ETAR) and also particular histological parameters.
Strategies in Preventing Diabetes after Pancreatectomy Using Islet Auto- and Allo-Transplantation
Over the years, pancreatectomy has been the primary treatment for chronic pancreatitis. Since the 1970s, total pancreatectomy has been shown to be effective at relieving pain that was experienced due to chronic pancreati...
Skin Lesions after Kidney Transplantation: An updated Review Including Recent Rare Cases
Skin disease is a significant cause of morbidity in chronically immunosuppressed patients, including organ transplant recipients. Cutaneous neoplasms are much more common in renal transplant recipients than in the genera...
Blockade of ASC but not NLRP3 Inhibits DC Proliferation and T cell Activation in Response to Alloantigen
The NLRP3 inflammasome is a multimeric protein complex consisting of the sensor molecule NACHT, LRR and PYD domains-containing protein 3 (NLRP3), the adaptor molecule Apoptosis-associated speck-like protein containing a...
Review of Bacterial Urinary Tract Infection in Kidney Transplant Recipients: Incidence, Risk Factors and Impact on the Graft Survival
Infectious complications remain a major cause of morbidity and mortality among transplant recipients. Urinary tract infection (UTI) is the most common infectious complication in kidney transplant recipients with a report...
Complications after Heart Transplantation: Hope for the Best, but Prepare for the Worst
For selected patients living with the most advanced stages of heart failure, cardiac transplantation is considered the gold-standard treatment, providing substantial improvements in survival and quality of life. However,...