B-Type Natriuretic Peptide in Bronchiolitis: Its Relationship with Left Ventricular Systolic Functions and Prognosis
Journal Title: Çocuk Acil ve Çocuk Yoğun Bakım Dergisi - Year 2018, Vol 5, Issue 3
Abstract
Introduction: We have limited information about the clinical importance of plasma B-type natriuretic peptide (BNP) level and its prognostic value in children with bronchiolitis. In this study, we aimed to determine basal plasma BNP levels and their relationship with left ventricular systolic functions and prognosis in patients hospitalized with moderate to severe bronchiolitis. Methods: The study was conducted prospectively on 37 patients aged 1-24 months with a modified Wang respiratory score of 6 and above and diagnosed with bronchiolitis. The patients with high (>100 pg/mL, n=6) and normal (≤100 pg/mL, n=31) serum BNP levels were compared in terms of left ventricular systolic functions, and vital, laboratory, and radiological findings. The relationship between serum BNP level and prognosis was evaluated. Results: The mean basal plasma BNP level in the patients was significantly higher than in controls (61.75±65 pg/mL vs. 13.99±8.79 pg/mL; p=0.001). There was no significant difference in ejection fraction and fractional shortening values between the patients with normal and high BNP levels and controls (p>0.05). Patients with high BNP levels had higher mean partial carbon dioxide values than patients with normal BNP levels (p=0.037). There was a positive correlation between plasma BNP level and length of hospital stay (r=0.286; p=0.007) and intensive care unit stay (r=0.645; p=0.000). Conclusion: An increase in serum BNP levels may be seen in patients with moderate to severe bronchiolitis without myocardial dysfunction. It was argued that this BNP increase may be related to the degree of deterioration of gas exchange associated with the disease. Plasma BNP level is a potential prognostic factor in moderate to severe bronchiolitis.
Authors and Affiliations
Gülşen Kes, Gülser Esen Besli, Yusuf İzzet Ayhan, Nurdan Erol, Ferruh Kemal İşman
Keywords
Related Articles
- EP ID EP538350
- DOI 10.4274/cayd.18291
- Views 115
- Downloads 0
Percutaneous Cholecystostomy for Acute Calculous Cholecystitis in Elderly Patients
Objectives: To investigate the efficacy, safety, recurrence and reintervention rates of percutaneous cholecystostomy (PC) in elderly patients with acute calculous cholecystitis (ACC). Materials and Methods: The data of t...
A Surprising Outcome of a Patient with Psychosis: Progressive Emphysema Associated with Pneumorrhachis
Air can be detected in various anatomical regions during the course of several diseases. This accumulation of air is often seen as pneumothorax and subcutaneous emphysema. Rarely extraordinary regions such as skull base...
Response From Authors: Evaluation of Patients Diagnosed with Brain Death in Pediatric Critical Care
.
A Study of the Approaches to Treating Missing Data in the Data Collected with the WHODAS 2.0 Scale
The aim of this study was to evaluate whether missing data rates are indicated in articles which applied World Health Organization Disability Assessment Schedule 2.0 scale (WHODAS 2.0); and to determine if missing data a...
Pediatric Fractures Secondary to Trampoline Injury: A Prospective Analysis of User Circumstances and Injury Severity with Respect to American Academy of Pediatrics Policy Statement
Introduction: The purpose of this study was to prospectively analyze injury patterns and severity with respect to American Academy of Pediatrics/Council on Sports Medicine and Fitness (AAP/CSMF) safety guidelines, and to...