Bacterial Infections In Hospitalized Patients With Liver Cirrhosis In A Tertiary Care Hospital
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 8
Abstract
Background And Aim: Patients with liver cirrhosis have a high risk of developing bacterial infections. The prevalence of bacterial infections is about 25-39% in hospitalized cirrhotic patients. There is scarcity of reports on the epidemiology of bacterial infections in cirrhotics from this region. Therefore this study was carried out with an aim to evaluate the prevalence, type and etiology of bacterial infections and pattern of antibiotic resistance in cirrhotics. Result: Consecutive 60 cirrhotics patients with bacterial infections were included in the study. Male outnumbered the females (Male: Female – 3:1). Mean age of presentation was 49.73±11.59 years. Most common cause of underlying cirrhosis was alcohol related (60%). Baseline CTP and MELD were 8.5±1.7 and 17.75±9.23 respectively. Mean duration of hospitalization was 12.38±9.73 days. 53.33% patients had severe hypoalbuminemia (< 2.5 gm%) and received albumin infusion. 66.66% patients had ascites. Most common bacterial infection was urinary tract infection (66.66%) with most common isolate as Klebsiella pneumoniae (40%) followed by E.coli (26.66%). Antibiotic resistance was found most commonly with cephalosporin (80%) followed by amoxicillin-clavulanic acid (60%) and quinolones (60%). Antibiotic resistance was least commonly found with tigecycline (0%), and vancomycin (0%) followed by linezolid (0.06%). Most common antibiotic prescribed was piperacillin-tazobactum (40%). All the patients responded to the antibiotics. Conclusion: Most common bacterial infection was urinary tract infection with Klebsiella pneumoniae as the most common isolate with zero resistance to tigecycline and vancomycin in the hospitalized cirrhotic patients from our region.
Authors and Affiliations
Girish Kumar Pati
Keywords
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