Bacteriological profile and their Antibiotic Sensitivity Pattern in Diabetic Foot Infections in a Tertiary Care Hospital
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 5
Abstract
Abstract: Diabetes mellitus (DM) is a metabolic disorder of endocrine system which is a major health problem with rising prevalence worldwide and is associated with several complications. In India it is estimated to have 61.3% million cases.Seven lakhs new cases are diagnosed every year in which Diabetic foot Infection (DFI) is one of the leading cause of hospitalization which may also lead to amputation of infected foot, if not treated promptly. The present study was conducted to isolate and identify the bacterial pathogens associated with DFI and to find out the antibiotic susceptibility pattern of these isolates. A total of 110 samples were collected from patients with Diabetic foot Infection during the period of Jan 2016- Dec 2016, after taking informed consent. The specimens were subjected to bacteriological study by Gram’s staining and culture according to standard guidelines. Isolates were identified and antibiotic susceptibility testing was done. Results: Out of 110 samples (total of 119 isolates), single organism was isolated from 73 (66.4%) samples and mixed bacterial growth was seen in 23 (20.9%) samples. Fourteen samples (12.7%) did not show any bacterial growth. In the present study gram negative organisms were isolated frequently (72.3%) than gram positive organisms (27.7%). Klebsiella pneumonia (37.2%) and Pseudomonas aeruginosa (25.6%) were the predominant gram negative bacilli whereas Methicillin Resistant Staphylococcus aureus (MRSA) (36.4%) was the most predominant in gram positive organisms. Among gram negative isolates 81.4% were susceptible to polymyxin-B followed by imipenem (76.7%), meropenem (67.4%), piperacillin/tazobactam (63.9%), cephalothin (20.9%) and ceftazidime (12.8%). Gram positive isolates were 100% susceptible to vancomycin and linezolid, followed by tetracycline (78.9%), gentamicin (75.8%), cephalothin, erythromycin and co-amoxyclav (51.5%).Conclusion: Both gram positive cocci and gram negative bacilli caused DFI and in this study there is predominance of gram negative organisms mainly Klebsiella pneumonia and Pseudomonas aeruginosa and among gram positive organisms MRSA was frequently isolated. Keywords:Antibiotic susceptibility, Bacterial isolates, Diabetic foot infections, Gram negative isolates, MRSA
Authors and Affiliations
Pradeep M. S. S, Vishnuvardhanarao K, Setty C. R
Keywords
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