Bacteriological Study of Early Onset and Late Onset Neonatal Septicaemia in a Tertiary Care Hospital in South India
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 7
Abstract
Introduction: Neonatal septicaemia is a clinical syndrome characterised by signs and symptoms of infection with or without accompanying bacteraemia in the first month of life. It is classified into early onset sepsis within 72 hour of life and late onset sepsis after 72 hour. The varying microbiological pattern of septicemia and their high antibiotic resistance needs to be studied. Material and Methods: This retrospective observational study was conducted for a period of one year. The bacterial isolates and their antibiogram from blood samples of clinically suspected neonatal septicaemic cases were studied from the records of Microbiology Laboratory. Results:Among 350 blood samples collected from clinically suspected cases of neonatal septicaemia,50(14.2%) were culture positive. Among 50 isolates, 41(82%) were from Early onset septicaemia and 9(18%) were from Late onset septicaemia. The predominant isolate in Early Onset Septicaemia and Late Onset Septicaemia was Klebsiella pneumoniae and Escherichia coli respectively followed by Staphylococcus aureus. Klebsiella showed high resistance to all the antibiotics and was most sensitive to meropenem (82.3%). All other Gram negative bacteria were 100% sensitive to Meropenem, Imipenem and Amikacin.The Gram positive bacteria showed 92% resistance to penicillin and were 100% sensitive to vancomycin and linezolid. Conclusion: In our study, Klebsiella pneumoniae was predominantly isolated. The susceptibility of the bacteria to the commonly used antibiotics was low and needs increased efforts to ensure rational use of antibiotics.
Authors and Affiliations
Mamatha P Samaga, Keerthi B. F, Sini Joseph
Keywords
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