Bayesian Joint Modelling of Disease Progression Marker and Time to Death Event of HIV/AIDS Patients under ART Follow-up
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 5, Issue 8
Abstract
Objectives: To develop separate and joint statistical models in the Bayesian framework for longitudinal measurements and time to death event data of HIV/AIDS patients. Study design: Longitudinal study. Place and Duration of Study: The population of study includes all HIV/AIDS patients who had been under follow up of Antiretroviral Therapy (ART) from January 2006 to December 2012 at Shashemene Referral Hospital in Ethiopia. Methodology: The posterior model was analyzed using Gibbs sampler by sampling from the distributions of the parameters given the data. Convergence of each sample was maintained. Results: The results indicated that the joint model was not significant indicating that the CD4 count did not have significant effect on the patient’s survival time. The results of both the separate and joint analyses were consistent. The separate model was better interims of goodness of fitness than the joint model, while the final joint model was found to be simpler (less complex) model than the separate models. In the longitudinal sub-model, the predictors: linear time, squared time, sex, and tobacco addiction were statistically significant at 0.05 level of significance. For the survival submodel, knowledge of ART and condom use were significantly related with time to death. Conclusion: The Bayesian Joint model provides results consistent with that of the separate models.
Authors and Affiliations
Gemeda Bedaso Buta, Ayele Taye Goshu, Hailemichael M. Worku
Keywords
Related Articles
- EP ID EP347079
- DOI 10.9734/BJMMR/2015/12907
- Views 77
- Downloads 0
Interventional Management of High-risk Patients with Takayasu’s Arteritis
Takayasu’s arteritis is a chronic vasculitis affecting aorta and its branches. We report a case series of Takayasu’s disease. Percutaneous intervention with stent implantation is better choice for stenosis and occlusion...
Rare Case of Multifocal Cutaneous Tuberculosis Verrucosa Cutis: Posing Clinical and Histopathological Diagnostic Dilemma
Introduction: Tuberculosis is an ancient universal health problem, with cutaneous tuberculosis being a rare extra pulmonary form that accounts for only 0.15-2%. Here we report a case of elderly female diagnosed with mult...
Y Chromosome Microdeletions and Partial AZFc Deletions in Infertile Men from South India
Aim: Yq microdeletions involving the azoospermia factor (AZF) region are the second most frequent genetic cause of spermatogenic failure next to Klinefelter syndrome. These deletions occur in about 10-15 percent of men w...
Prevalence of Tooth Wear Due to Dietary Factors in South Canara Population
Aims: The aim of the study was to determine the prevalence of tooth wear due to dietary factors in South Canara population. Place and Duration of Study: Department of Conservative Dentistry and Endodontics, A.B. Shetty M...
Prevalence and Antibiotic Susceptibility Pattern of Pathogens Isolated from Post-Operative Wounds of Diabetes Mellitus Patients in Uyo, Nigeria
This study was aimed at investigating the prevalence and antibiotic susceptibility of isolates from wounds of diabetic and non diabetic patients in University of Uyo metropolis. Eighty five wound swab samples were collec...