BENEFICIAL EFFECTS OF ERYTHROPOIETIN ON STRIATAL DOPAMINERGIC NEURONS IN 6-OHDA-TREATED AGED RAT MODEL OF PARKINSON’S DISEASE
Journal Title: International Journal of Basic and Applied Physiology - Year 2015, Vol 4, Issue 1
Abstract
Background & objectives: It has been reported that erythropoietin played important role in prevention of striatal dopaminergic neurons loss against 6-hydroxydopamine (6-OHDA) in young rats. As the degeneration of dopaminergic neurons occurred commonly in aged individuals. The present study was undertaken to investigate the beneficial effects of erythropoietin against 6hydroxydopamine neurotoxicity in aged rat model of Parkinson’s disease. Literature is silent about it. Methods: Sprague-Dawley rats were pre-treated with erythropoietin and subsequently administered the neurotoxin 6-hydroxydopamine into the aged rat striatum. Various behaviour and immunohisotochemical tests were used to investigate the beneficial effects of erythropoietin. Results: Statistically significant difference was found between post-lesion values of all groups (ANOVA, P<0.001 in apomorphine-induced rotational behaviour, staircase test (success rate) and disengage time; P<0.05 in stepping test, initiation time and postural balance test). Erythropoietin also increased more survival of dopaminergic neurons in the 6-OHDA lesioned striatum. Interpretation & conclusion: On the basis of changes in these tests, the present study concludes that erythropoietin enhances the beneficial effects in 6-OHDA treated aged rat. Howsoever less improvement are found in aged rats than that of young rats.
Authors and Affiliations
Manisha Gautam, Shalu Chandra, Ravinder Kumar Saran, Shyama Jain, Bal Krishana
Keywords
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